-transparent.png){kind=logo}
Dose-response curves to aerosol histamine in 102 anesthetized, intubated, spontaneously breathing dogs revealed a spectrum of airway responsiveness with a greater than 40-fold difference between the most and the least sensitive animals. The frequency distribution of responses fits a log normal distribution. No correlation was found between sex, age, or control values of dynamic compliance (Cdyn) and lung resistance (RL) and the dose of histamine required to cause a response. Repetitive studies in 17 dogs observed for up to 20 mo showed that the dose at which an individual dog would respond was reproducible within a narrow range and that the differences between dogs were highly significant (P greater than 0.001). The long-term reproducibility of the response to aerosol histamine in individual dogs suggests that short-term reversible airway insults are not responsible for the range in responses noted between animals.
J R Snapper, and
J M Drazen, and
S H Loring, and
W Schneider, and
R H Ingram
February 1984,
Journal of applied physiology: respiratory, environmental and exercise physiology,
J R Snapper, and
J M Drazen, and
S H Loring, and
W Schneider, and
R H Ingram
December 1984,
Journal of applied physiology: respiratory, environmental and exercise physiology,
J R Snapper, and
J M Drazen, and
S H Loring, and
W Schneider, and
R H Ingram
June 1983,
Journal of applied physiology: respiratory, environmental and exercise physiology,
J R Snapper, and
J M Drazen, and
S H Loring, and
W Schneider, and
R H Ingram
February 1998,
American journal of respiratory and critical care medicine,
J R Snapper, and
J M Drazen, and
S H Loring, and
W Schneider, and
R H Ingram
January 1985,
The American review of respiratory disease,
J R Snapper, and
J M Drazen, and
S H Loring, and
W Schneider, and
R H Ingram
September 1997,
Japanese circulation journal,
J R Snapper, and
J M Drazen, and
S H Loring, and
W Schneider, and
R H Ingram
October 1977,
Journal of applied physiology: respiratory, environmental and exercise physiology,
J R Snapper, and
J M Drazen, and
S H Loring, and
W Schneider, and
R H Ingram
January 1986,
Respiration; international review of thoracic diseases,
J R Snapper, and
J M Drazen, and
S H Loring, and
W Schneider, and
R H Ingram
July 1986,
The Journal of allergy and clinical immunology,
J R Snapper, and
J M Drazen, and
S H Loring, and
W Schneider, and
R H Ingram
June 1987,
The American review of respiratory disease,
