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The antimuscarinic activity of oxybutynin was measured as oxybutynin equivalents by a radioreceptor assay (RRA). The activity was studied in plasma samples of five volunteers after a single oral dose (10 mg) or after a single intravenous dose (28 micrograms/kg) of oxybutynin hydrochloride. The results were compared to the concentrations of the drug measured by gas liquid chromatography (GLC). Following oral administration, the maximum concentration measured by RRA was significantly higher (706 nmol/l) than that by GLC (38 nmol/l). In contrast, equal concentrations were measured after intravenous administration by both methods. Metabolites with antimuscarinic activity are possibly formed through first-pass metabolism after orally administered oxybutynin. The total antimuscarinic activity of oxybutynin and its metabolites are measured by RRA, but only the parent drug by GLC.
L Aaltonen, and
H Allonen, and
E Iisalo, and
A Juhakoski, and
T Kleimola, and
R Sellman
May 1987,
Oral surgery, oral medicine, and oral pathology,
L Aaltonen, and
H Allonen, and
E Iisalo, and
A Juhakoski, and
T Kleimola, and
R Sellman
January 1987,
European journal of clinical pharmacology,
L Aaltonen, and
H Allonen, and
E Iisalo, and
A Juhakoski, and
T Kleimola, and
R Sellman
January 1988,
Journal of pharmaceutical and biomedical analysis,
L Aaltonen, and
H Allonen, and
E Iisalo, and
A Juhakoski, and
T Kleimola, and
R Sellman
December 1987,
Pharmaceutisch weekblad. Scientific edition,
L Aaltonen, and
H Allonen, and
E Iisalo, and
A Juhakoski, and
T Kleimola, and
R Sellman
February 1991,
Journal of pharmaceutical sciences,
L Aaltonen, and
H Allonen, and
E Iisalo, and
A Juhakoski, and
T Kleimola, and
R Sellman
September 1982,
The Journal of clinical endocrinology and metabolism,
L Aaltonen, and
H Allonen, and
E Iisalo, and
A Juhakoski, and
T Kleimola, and
R Sellman
December 1985,
Biochemical and biophysical research communications,
L Aaltonen, and
H Allonen, and
E Iisalo, and
A Juhakoski, and
T Kleimola, and
R Sellman
May 1984,
Pharmacological research communications,
L Aaltonen, and
H Allonen, and
E Iisalo, and
A Juhakoski, and
T Kleimola, and
R Sellman
April 1982,
Endocrinologia japonica,
L Aaltonen, and
H Allonen, and
E Iisalo, and
A Juhakoski, and
T Kleimola, and
R Sellman
July 1976,
Acta endocrinologica,
