Serum and cerebrospinal fluid concentrations of immunoglobulin G in Suffolk sheep with scrapie. 1984

G M Strain, and O Barta, and B M Olcott, and W F Braun

Determinations were made by laser nephelometry of serum and CSF immunoglobulin (Ig) G concentrations in Suffolk sheep with naturally occurring scrapie. The serum IgG concentrations in 3 sheep with confirmed or suspected scrapie were between 2,140 and 3,290 mg of IgG/100 ml, and the CSF values were between less than 10 and 75 mg of IgG/100 ml. In 8 clinically healthy (control) sheep, serum IgG concentrations were 2,647 to 7,380 mg/100 ml and CSF IgG concentrations were between 0 (undetectable) and 162 mg/100 ml. A sheep with pulmonary adenomatosis had 1,445 mg of IgG/100 ml of serum. The results indicated that neither serum nor CSF IgG concentrations were increased in sheep with naturally occurring infection with scrapie and that the severity of the disease did not correspond with the IgG concentration.

UI MeSH Term Description Entries
D007074 Immunoglobulin G The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B. Gamma Globulin, 7S,IgG,IgG Antibody,Allerglobuline,IgG(T),IgG1,IgG2,IgG2A,IgG2B,IgG3,IgG4,Immunoglobulin GT,Polyglobin,7S Gamma Globulin,Antibody, IgG,GT, Immunoglobulin
D011648 Pulmonary Adenomatosis, Ovine A contagious, neoplastic, pulmonary disease of sheep characterized by hyperplasia and hypertrophy of pneumocytes and epithelial cells of the lung. It is caused by JAAGSIEKTE SHEEP RETROVIRUS. Adenomatosis, Pulmonary, Ovine,Carcinoma, Ovine Pulmonary,Jaagsiekte,Adenomatosis, Ovine Pulmonary,Ovine Pulmonary Adenomatosis,Ovine Pulmonary Carcinoma,Pulmonary Ovine Adenomatosis,Adenomatoses, Ovine Pulmonary,Adenomatoses, Pulmonary Ovine,Adenomatosis, Pulmonary Ovine,Carcinomas, Ovine Pulmonary,Ovine Adenomatoses, Pulmonary,Ovine Adenomatosis, Pulmonary,Ovine Pulmonary Adenomatoses,Ovine Pulmonary Carcinomas,Pulmonary Adenomatoses, Ovine,Pulmonary Carcinoma, Ovine,Pulmonary Carcinomas, Ovine,Pulmonary Ovine Adenomatoses
D005260 Female Females
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012608 Scrapie A fatal disease of the nervous system in sheep and goats, characterized by pruritus, debility, and locomotor incoordination. It is caused by proteinaceous infectious particles called PRIONS. Rida
D012756 Sheep Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS. Ovis,Sheep, Dall,Dall Sheep,Ovis dalli

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