-transparent.png){kind=logo}
Ethylene glycol, a major constituent of antifreeze, is metabolized by alcohol dehydrogenase to glycoaldehyde, glycolate, glyoxylate, and oxalate. The metabolites of ethylene glycol cause severe metabolic acidosis and central nervous system, pulmonary, and renal damage. Ethanol competes with ethylene glycol as an alternate substrate of alcohol dehydrogenase. Two cases of ethylene glycol poisoning associated with serum concentrations of 59 and 150 mg/dl are reported. One patient was protected from the toxic effects of the metabolites because of concomitant ethanol ingestion. In patients with unexplained anion and osmol gaps, early diagnosis and therapy with ethanol and hemodialysis help prevent the toxic manifestations of ethylene glycol poisoning.
R DaRoza, and
R J Henning, and
I Sunshine, and
C Sutheimer
October 1961,
Svenska lakartidningen,
R DaRoza, and
R J Henning, and
I Sunshine, and
C Sutheimer
October 1987,
Wiadomosci lekarskie (Warsaw, Poland : 1960),
R DaRoza, and
R J Henning, and
I Sunshine, and
C Sutheimer
January 1977,
Acta pharmacologica et toxicologica,
R DaRoza, and
R J Henning, and
I Sunshine, and
C Sutheimer
April 1993,
Journal of emergency nursing,
R DaRoza, and
R J Henning, and
I Sunshine, and
C Sutheimer
January 1976,
European journal of toxicology and environmental hygiene. Journal europeen de toxicologie,
R DaRoza, and
R J Henning, and
I Sunshine, and
C Sutheimer
October 1985,
Critical care medicine,
R DaRoza, and
R J Henning, and
I Sunshine, and
C Sutheimer
January 1983,
Sudebno-meditsinskaia ekspertiza,
R DaRoza, and
R J Henning, and
I Sunshine, and
C Sutheimer
May 1970,
European journal of toxicology,
R DaRoza, and
R J Henning, and
I Sunshine, and
C Sutheimer
January 1984,
Terapevticheskii arkhiv,
R DaRoza, and
R J Henning, and
I Sunshine, and
C Sutheimer
May 1974,
Wiadomosci lekarskie (Warsaw, Poland : 1960),
