BIOMAT Database Logo BIOMAT Database Logo

[Possibility of N-dimethylnitrosamine formation after parenteral administration of amidopyrine and nitrite to rats]. 1984

B L Rubenchik, and V F Tsapenko, and T M Boĭm

The intravenous or intraperitoneal injection of amidopyrine and sodium nitrite to rats induces liver necrosis caused by endogenic synthesis of carcinogenic N-nitrosodimethylamine (NDMA). Ascorbic acid, which inhibits this synthesis when injected intravenously, phenobarbital, which is an inductor of enzymatic decomposition when injected intraperitoneally, prevented the formation of necrosis.

UI MeSH Term Description Entries
D007274 Injections, Intraperitoneal Forceful administration into the peritoneal cavity of liquid medication, nutrient, or other fluid through a hollow needle piercing the abdominal wall. Intraperitoneal Injections,Injection, Intraperitoneal,Intraperitoneal Injection
D007275 Injections, Intravenous Injections made into a vein for therapeutic or experimental purposes. Intravenous Injections,Injection, Intravenous,Intravenous Injection
D008099 Liver A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances. Livers
D008297 Male Males
D009336 Necrosis The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
D009573 Nitrites Salts of nitrous acid or compounds containing the group NO2-. The inorganic nitrites of the type MNO2 (where M Nitrite
D010634 Phenobarbital A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations. Phenemal,Phenobarbitone,Phenylbarbital,Gardenal,Hysteps,Luminal,Phenobarbital Sodium,Phenobarbital, Monosodium Salt,Phenylethylbarbituric Acid,Acid, Phenylethylbarbituric,Monosodium Salt Phenobarbital,Sodium, Phenobarbital
D004128 Dimethylnitrosamine A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties. It causes serious liver damage and is a hepatocarcinogen in rodents. Nitrosodimethylamine,N-Nitrosodimethylamine,NDMA Nitrosodimethylamine,N Nitrosodimethylamine,Nitrosodimethylamine, NDMA
D000632 Aminopyrine A pyrazolone with analgesic, anti-inflammatory, and antipyretic properties but has risk of AGRANULOCYTOSIS. A breath test with 13C-labeled aminopyrine has been used as a non-invasive measure of CYTOCHROME P-450 metabolic activity in LIVER FUNCTION TESTS. Amidophenazon,Aminophenazone,Dimethylaminophenazone,Dipyrine,Amidazophen,Amidophen,Amidopyrine,Aminofenazone,Dimethyl-N-aminoantipyrine,Dimethylaminoantipyrine,Eufibron,Dimethyl N aminoantipyrine
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

Related Publications

B L Rubenchik, and V F Tsapenko, and T M Boĭm
[Possibility of endogenous dimethylnitrosamine synthesis in rats administered dimethylamine and nitrite with the food].
January 1980, Voprosy pitaniia,
B L Rubenchik, and V F Tsapenko, and T M Boĭm
Experiments on the detection of the carcinogenic N-nitroso-dimethylamine in the urine of rats after oral administration of the analgesic amidopyrine and nitrite.
January 1976, Arzneimittel-Forschung,
B L Rubenchik, and V F Tsapenko, and T M Boĭm
[Transplacental formation of malignant tumors after oral administration of ethylurea and nitrite to rats].
September 1970, Die Naturwissenschaften,
B L Rubenchik, and V F Tsapenko, and T M Boĭm
In-vivo formation of N-nitrosodimethylamine in humans after amidopyrine intake.
January 1984, IARC scientific publications,
B L Rubenchik, and V F Tsapenko, and T M Boĭm
[Possibility of in vivo formation of N-nitroso compounds from drugs and nitrite (author's transl)].
January 1981, Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences,
B L Rubenchik, and V F Tsapenko, and T M Boĭm
Anticonvulsant activities of N-benzyloxycarbonylglycine after parenteral administration.
March 1994, Neuroreport,
B L Rubenchik, and V F Tsapenko, and T M Boĭm
Formation of ethyl nitrite in vivo after ethanol administration.
January 2004, Alcohol (Fayetteville, N.Y.),
B L Rubenchik, and V F Tsapenko, and T M Boĭm
Nitrate, nitrite, dimethylnitrosamine and N-nitrosopyrrolidine in some Chinese food products.
April 1977, Food and cosmetics toxicology,
B L Rubenchik, and V F Tsapenko, and T M Boĭm
THE FORMATION OF CONDITIONED REFLEXES IN RATS AFTER THE PARENTERAL ADMINISTRATION OF BRAIN HOMOGENATE.
January 1965, Activitas nervosa superior,
B L Rubenchik, and V F Tsapenko, and T M Boĭm
Measurement of 7-methylguanine as an estimate of the amount of dimethylnitrosamine formed following administration of aminopyrine and nitrite to rats.
November 1983, Cancer research,
Copied contents to your clipboard!