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Six cephalosporin antibiotics (cefamandole, cefazolin, cephacetrile, cephalothin, cephaloridine, and cephradine) and two penicillin (ampicillin and penicillin G) were evaluated in vitro and in a rabbit model of experimental meningitis due to Haemophilus influenzae or Streptococcus pneumoniae. The percentage penetration ([concentration in cerebrospinal fluid/concentration in serum] X 100%) of these antibiotics varied from 0.7% for cephalothin to 17% for cephaloridine. The penetration varied inversely with binding to serum proteins. The bactericidal rate of all of the cephalosporin antibiotics was similar in vitro and in vivo to that of penicillin G. However, as demonstrated with cephalothin, concentrations considerably above the minimal bactericidal concentration (as determined in broth) were necessary to initiate the bactericidal effect. Cefamandole was found to be as effective as ampicillin in the therapy of H. influenzae meningitis in rabbits.
M A Sande, and
R J Sherertz, and
O Zak, and
L J Strausbaugh
October 1996,
Enfermedades infecciosas y microbiologia clinica,
M A Sande, and
R J Sherertz, and
O Zak, and
L J Strausbaugh
February 1983,
Antimicrobial agents and chemotherapy,
M A Sande, and
R J Sherertz, and
O Zak, and
L J Strausbaugh
January 1996,
Antimicrobial agents and chemotherapy,
M A Sande, and
R J Sherertz, and
O Zak, and
L J Strausbaugh
January 1983,
Scandinavian journal of infectious diseases. Supplementum,
M A Sande, and
R J Sherertz, and
O Zak, and
L J Strausbaugh
February 1982,
Antimicrobial agents and chemotherapy,
M A Sande, and
R J Sherertz, and
O Zak, and
L J Strausbaugh
January 1992,
Revue de pneumologie clinique,
M A Sande, and
R J Sherertz, and
O Zak, and
L J Strausbaugh
March 1997,
Enfermedades infecciosas y microbiologia clinica,
M A Sande, and
R J Sherertz, and
O Zak, and
L J Strausbaugh
February 1977,
The Journal of infectious diseases,
M A Sande, and
R J Sherertz, and
O Zak, and
L J Strausbaugh
January 2004,
Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases,
M A Sande, and
R J Sherertz, and
O Zak, and
L J Strausbaugh
September 1978,
British medical journal,
