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A new glucose 6-phosphate dehydrogenase (G6PD) variant associated with chronic nonspherocytic hemolytic anemia was discovered in Japan. The patient showed hemolytic crises after upper respiratory infections. The enzyme activity was about 3.8% of the normal. The partially purified enzyme revealed slow anodal electrophoretic mobility, high Km NADP, marked thermal-instability, and increased affinity for a substrate analogue (deamino-NADP). A particular characteristic of this enzyme was a biphasic pH curve with a greatly increased activity at low pH values. From these results, this variant was clearly different from hitherto observed G6PD variants, and was designated G6PD Asahikawa.
T Takizawa, and
H Fujii, and
S Takegawa, and
K Takahashi, and
A Hirono, and
T Morisaki, and
H Kanno, and
R Oka, and
H Yoshioka, and
S Miwa
January 1989,
Human genetics,
T Takizawa, and
H Fujii, and
S Takegawa, and
K Takahashi, and
A Hirono, and
T Morisaki, and
H Kanno, and
R Oka, and
H Yoshioka, and
S Miwa
November 1969,
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T Takizawa, and
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S Miwa
September 1968,
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T Takizawa, and
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S Miwa
January 1971,
Enzyme,
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March 1995,
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December 2004,
Nihon rinsho. Japanese journal of clinical medicine,
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R Oka, and
H Yoshioka, and
S Miwa
January 1981,
Human genetics,
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S Miwa
July 1978,
Human genetics,
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S Miwa
January 1988,
Human genetics,
T Takizawa, and
H Fujii, and
S Takegawa, and
K Takahashi, and
A Hirono, and
T Morisaki, and
H Kanno, and
R Oka, and
H Yoshioka, and
S Miwa
February 1994,
American journal of hematology,
