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In order to determine the effect of relaxin and estradiol on collagen and noncollagen synthesis by mammary gland fibroblasts, fibroblasts isolated from guinea pig mammary glands were grown on plastic or Cytodex-3 collagen coated microcarriers. On plastic, estradiol (600 pg/ml) increased the incorporation of tritiated glycine into collagen. Non-collagenous protein synthesis was increased at all concentrations of estradiol, but it was greatest with 200 pg/ml estradiol. On Cytodex-3, 400 pg/ml estradiol increased the synthesis of collagen and non-collagenous protein. Relaxin (1 microgram/ml) did not affect collagen synthesis but decreased the synthesis of non-collagenous protein.
L G Sheffield, and
R R Anderson
January 1974,
Connective tissue research,
L G Sheffield, and
R R Anderson
June 1990,
The Journal of biological chemistry,
L G Sheffield, and
R R Anderson
December 1978,
In vitro,
L G Sheffield, and
R R Anderson
October 1985,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
L G Sheffield, and
R R Anderson
September 1992,
The Journal of investigative dermatology,
L G Sheffield, and
R R Anderson
January 1988,
Proceedings of the Finnish Dental Society. Suomen Hammaslaakariseuran toimituksia,
L G Sheffield, and
R R Anderson
September 1988,
Clinica chimica acta; international journal of clinical chemistry,
L G Sheffield, and
R R Anderson
March 1984,
Collagen and related research,
L G Sheffield, and
R R Anderson
January 1985,
Annals of the New York Academy of Sciences,
L G Sheffield, and
R R Anderson
May 1992,
Biochemical Society transactions,
