-transparent.png){kind=logo}
Cells from a dihydrofolate reductase-deficient Chinese hamster ovary cell line were hybridized to human fetal skin fibroblast cells. Nineteen dihydrofolate reductase-positive hybrid clones were isolated and characterized. Cytogenetic and biochemical analyses of these clones have shown that the human dihydrofolate reductase (DHFR) gene is located on chromosome 5. Three of these hybrid cell lines contained different terminal deletions of chromosome 5. An analysis of the breakpoints of these deletions has demonstrated that the DHFR gene resides in the q11----q22 region.
Related Publications
V L Funanage, and
T T Myoda, and
P A Moses, and
H R Cowell
January 1990,
Cytogenetics and cell genetics,
V L Funanage, and
T T Myoda, and
P A Moses, and
H R Cowell
January 1986,
Cytogenetics and cell genetics,
V L Funanage, and
T T Myoda, and
P A Moses, and
H R Cowell
January 1985,
Somatic cell and molecular genetics,
V L Funanage, and
T T Myoda, and
P A Moses, and
H R Cowell
January 1983,
Cytogenetics and cell genetics,
V L Funanage, and
T T Myoda, and
P A Moses, and
H R Cowell
January 1983,
Cytogenetics and cell genetics,
V L Funanage, and
T T Myoda, and
P A Moses, and
H R Cowell
June 1994,
Human genetics,
V L Funanage, and
T T Myoda, and
P A Moses, and
H R Cowell
January 1994,
Genomics,
V L Funanage, and
T T Myoda, and
P A Moses, and
H R Cowell
July 1989,
Genomics,
V L Funanage, and
T T Myoda, and
P A Moses, and
H R Cowell
January 1986,
Somatic cell and molecular genetics,
V L Funanage, and
T T Myoda, and
P A Moses, and
H R Cowell
December 1978,
Proceedings of the National Academy of Sciences of the United States of America,
