Biomaterial Database

Acute reactions of the lip mucosa of mice to fractionated irradiations. 1984

F X Xu, and E van der Schueren, and K K Ang

The acute reaction of the lip mucosa of mice after single and fractionated irradiations has been investigated. The mouths of 24 mice were irradiated simultaneously in a single field. It was found that the acute reaction of lip mucosa can easily and reliably be scored. The variation in scoring between different observers is small and the reaction is reproducible. The mucosal reaction starts at day 7, reaches a maximum at about day 11-12 and regresses rapidly during the following 6 to 7 days. The overall reaction period is thus shorter for lip mucosa than for skin in the mouse, indicating a shorter cell cycle time. Dose-response curves can be constructed by plotting the average reaction from day 8 to 17 versus the total dose. The curve of log isoeffect dose for an average reaction level 3 against log number of fractions has a slope of 0.35 for a dose rate of 200 cGy/min and 0.29 for 33 cGy/min. The dose required to induce focal mucosa desquamation is significantly lower than that necessary to produce spotted epidermolysis in skin (16.5 Gy vs. 33 Gy for single dose).

UI	MeSH Term	Description	Entries
D007413	Intestinal Mucosa	Lining of the INTESTINES, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. In the SMALL INTESTINE, the mucosa is characterized by a series of folds and abundance of absorptive cells (ENTEROCYTES) with MICROVILLI.	Intestinal Epithelium,Intestinal Glands,Epithelium, Intestinal,Gland, Intestinal,Glands, Intestinal,Intestinal Gland,Mucosa, Intestinal
D008046	Lip	Either of the two fleshy, full-blooded margins of the mouth.	Philtrum,Lips,Philtrums
D008954	Models, Biological	Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.	Biological Model,Biological Models,Model, Biological,Models, Biologic,Biologic Model,Biologic Models,Model, Biologic
D009061	Mouth Mucosa	Lining of the ORAL CAVITY, including mucosa on the GUMS; the PALATE; the LIP; the CHEEK; floor of the mouth; and other structures. The mucosa is generally a nonkeratinized stratified squamous EPITHELIUM covering muscle, bone, or glands but can show varying degree of keratinization at specific locations.	Buccal Mucosa,Oral Mucosa,Mucosa, Mouth,Mucosa, Oral
D004307	Dose-Response Relationship, Radiation	The relationship between the dose of administered radiation and the response of the organism or tissue to the radiation.	Dose Response Relationship, Radiation,Dose-Response Relationships, Radiation,Radiation Dose-Response Relationship,Radiation Dose-Response Relationships,Relationship, Radiation Dose-Response,Relationships, Radiation Dose-Response
D005260	Female		Females
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012867	Skin	The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
D051379	Mice	The common name for the genus Mus.	Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus