Biomaterial Database

Effects of pyrethroids on lymphocyte mitogenic responsiveness. 1984

K J Stelzer, and M A Gordon

The in vitro effects of pyrethroids on the mitogenic responsiveness of murine splenic lymphocytes to concanavalin A (Con A) and lipopolysaccharide (LPS) have been determined. Mitogenic stimulation was measured by uptake of [6-3H]-thymidine. Permethrin and cypermethrin inhibited the mitogenic response to Con A over a concentration range of 1 X 10(-5) M to 5 X 10(-5) M. Relative to these pyrethroids, slightly lower concentrations of fenpropathrin were required to inhibit mitogenic responsiveness to Con A. Fluvalinate was least effective of the pyrethroids tested, and caused mitogenic inhibition at concentrations of 1.5 X 10(-5) M to 5 X 10(-5) M. Unlike the other pyrethroids, concentrations of fluvalinate as high as 1 X 10(-4) M did not result in complete inhibition of the mitogenic response to Con A. Allethrin, was the most potent inhibitor, with effective concentrations in the range of 1 X 10(-6) M to 1.5 X 10(-5) M. Permethrin (3 X 10(-5) M) inhibited the mitogenic response at each of several concentrations of Con A tested, and did not cause a shift in the lymphocyte mitogenic dose-response to Con A. The mitogenic responsiveness to LPS was found to be inhibited by allethrin and permethrin at the same concentrations which inhibited the mitogenesis induced by Con A. The results support the possibility of immune suppression by pyrethroid exposure.

UI	MeSH Term	Description	Entries
D008213	Lymphocyte Activation	Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.	Blast Transformation,Blastogenesis,Lymphoblast Transformation,Lymphocyte Stimulation,Lymphocyte Transformation,Transformation, Blast,Transformation, Lymphoblast,Transformation, Lymphocyte,Activation, Lymphocyte,Stimulation, Lymphocyte
D011722	Pyrethrins	The active insecticidal constituent of CHRYSANTHEMUM CINERARIIFOLIUM flowers. Pyrethrin I is the pyretholone ester of chrysanthemummonocarboxylic acid and pyrethrin II is the pyretholone ester of chrysanthemumdicarboxylic acid monomethyl ester.	Pyrethrin,Pyrethroid,Pyrethroids
D003208	Concanavalin A	A MANNOSE/GLUCOSE binding lectin isolated from the jack bean (Canavalia ensiformis). It is a potent mitogen used to stimulate cell proliferation in lymphocytes, primarily T-lymphocyte, cultures.
D004305	Dose-Response Relationship, Drug	The relationship between the dose of an administered drug and the response of the organism to the drug.	Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D000487	Allethrins	Synthetic analogs of the naturally occurring insecticides cinerin, jasmolin, and pyrethrin. (From Merck Index, 11th ed)	Allethrin,Cyclopropanecarboxylic acid, 2,2-dimethyl-3-(2-methyl-1-propenyl)-, 2-methyl-4-oxo-3-(2-propenyl)-2-cyclopenten-1-yl ester
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013237	Stereoisomerism	The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)	Molecular Stereochemistry,Stereoisomers,Stereochemistry, Molecular,Stereoisomer
D051379	Mice	The common name for the genus Mus.	Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus
D026023	Permethrin	A pyrethroid insecticide commonly used in the treatment of LICE INFESTATIONS and SCABIES.	Cyclopropanecarboxylic Acid, 3-(2,2-dichloroethenyl)-2,2-dimethyl-, (3-phenoxyphenyl)methyl ester,(m-Phenoxybenzyl)-cis,trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate,3-Phenoxybenzyl-(+-)-cis,trans-2,2-dichlorovinyl-2,2-dimethyl-cyclopropylcarboxylic acid, ester,3-Phenoxybenzyl-cis,trans-(1RS)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate,Ambush,Elimite,FMC-33297,NIA-33297,NRDC-143,NRDC-147,Nittifor,PP-557,Permethrin, (1R-cis)-Isomer,Permethrin, (1R-trans)-Isomer,Permethrin, (1S-cis)-Isomer,Permethrin, (1S-trans)-Isomer,Permethrin, (cis)-Isomer,Permethrin, (cis-(+-))-Isomer,Permethrin, (trans)-Isomer,Permethrin, (trans-(+-))-Isomer,Permethrin, trans-(1RS)-Isomer,S-3151,cis-(1RS)-permethrin,cis-permethrin,permethrin, cis-(1RS)-isomer,trans-(1RS)-Permethrin,trans-permethrin,FMC 33297,FMC33297,NIA 33297,NIA33297,NRDC 143,NRDC 147,NRDC143,NRDC147,PP 557,PP557,S 3151,S3151,cis permethrin,trans permethrin
D066298	In Vitro Techniques	Methods to study reactions or processes taking place in an artificial environment outside the living organism.	In Vitro Test,In Vitro Testing,In Vitro Tests,In Vitro as Topic,In Vitro,In Vitro Technique,In Vitro Testings,Technique, In Vitro,Techniques, In Vitro,Test, In Vitro,Testing, In Vitro,Testings, In Vitro,Tests, In Vitro,Vitro Testing, In