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he authors used competitive protein binding assay and radioimmunoassay to measure cortisol levels in 38 normal control subjects three times before and three times after administration of 1 mg of dexamethasone. They found significant interassay differences at 11:00 p.m. before dexamethasone and at all three postdexamethasone times. Analysis of variance revealed significant overall positive relationships between age and cortisol levels measured by both techniques. Age correlated significantly with postdexamethasone cortisol levels measured by radioimmunoassay but not when measured by competitive protein binding assay. Clinicians should obtain data from their laboratories as to appropriate cutoffs for cortisol suppression on the specific assay used.
A H Rosenbaum, and
A F Schatzberg, and
R A MacLaughlin, and
K Snyder, and
N S Jiang, and
D Ilstrup, and
A J Rothschild, and
B Kliman
February 1983,
The American journal of psychiatry,
A H Rosenbaum, and
A F Schatzberg, and
R A MacLaughlin, and
K Snyder, and
N S Jiang, and
D Ilstrup, and
A J Rothschild, and
B Kliman
August 1984,
Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry,
A H Rosenbaum, and
A F Schatzberg, and
R A MacLaughlin, and
K Snyder, and
N S Jiang, and
D Ilstrup, and
A J Rothschild, and
B Kliman
January 1989,
Journal of psychiatric research,
A H Rosenbaum, and
A F Schatzberg, and
R A MacLaughlin, and
K Snyder, and
N S Jiang, and
D Ilstrup, and
A J Rothschild, and
B Kliman
March 1985,
Psychiatry research,
A H Rosenbaum, and
A F Schatzberg, and
R A MacLaughlin, and
K Snyder, and
N S Jiang, and
D Ilstrup, and
A J Rothschild, and
B Kliman
November 1985,
Biological psychiatry,
A H Rosenbaum, and
A F Schatzberg, and
R A MacLaughlin, and
K Snyder, and
N S Jiang, and
D Ilstrup, and
A J Rothschild, and
B Kliman
July 1984,
The American journal of psychiatry,
A H Rosenbaum, and
A F Schatzberg, and
R A MacLaughlin, and
K Snyder, and
N S Jiang, and
D Ilstrup, and
A J Rothschild, and
B Kliman
March 1984,
Biological psychiatry,
A H Rosenbaum, and
A F Schatzberg, and
R A MacLaughlin, and
K Snyder, and
N S Jiang, and
D Ilstrup, and
A J Rothschild, and
B Kliman
December 1982,
Psychiatry research,
A H Rosenbaum, and
A F Schatzberg, and
R A MacLaughlin, and
K Snyder, and
N S Jiang, and
D Ilstrup, and
A J Rothschild, and
B Kliman
March 1982,
The American journal of psychiatry,
A H Rosenbaum, and
A F Schatzberg, and
R A MacLaughlin, and
K Snyder, and
N S Jiang, and
D Ilstrup, and
A J Rothschild, and
B Kliman
November 1983,
The American journal of psychiatry,
