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A brief review of the neurochemical effects of the convulsant agent L-methionine-dl-sulfoximine (MSO) on cerebral methylation reactions is presented. Our findings point to the involvement of a number of endogenous methyl acceptor molecules, including histamine, membrane phospholipids, and membrane proteins, in the mediation of the convulsant effect. Our findings also associate the inhibition of methylations by high levels of S-adenosyl-L-homocysteine in brain with protection against MSO-induced seizures. We propose that MSO acts by eliciting the acceleration of a regulatory methylation-demethylation sequence at key molecular sites, including the benzodiazepine receptor complex, which creates an imbalance in this sequence's normal mediation of convulsant-anticonvulsant mechanisms.
O Z Sellinger, and
R A Schatz, and
R Porta, and
T E Wilens
October 1995,
Neuroreport,
O Z Sellinger, and
R A Schatz, and
R Porta, and
T E Wilens
March 1965,
Ceskoslovenska fysiologie,
O Z Sellinger, and
R A Schatz, and
R Porta, and
T E Wilens
January 1978,
Biochemical pharmacology,
O Z Sellinger, and
R A Schatz, and
R Porta, and
T E Wilens
December 1970,
Rivista di patologia nervosa e mentale,
O Z Sellinger, and
R A Schatz, and
R Porta, and
T E Wilens
June 1970,
Proceedings of the National Academy of Sciences of the United States of America,
O Z Sellinger, and
R A Schatz, and
R Porta, and
T E Wilens
September 1954,
Archives of biochemistry and biophysics,
O Z Sellinger, and
R A Schatz, and
R Porta, and
T E Wilens
June 1969,
Biochemistry,
O Z Sellinger, and
R A Schatz, and
R Porta, and
T E Wilens
June 1982,
Brain research,
O Z Sellinger, and
R A Schatz, and
R Porta, and
T E Wilens
February 1953,
The Journal of biological chemistry,
O Z Sellinger, and
R A Schatz, and
R Porta, and
T E Wilens
January 1981,
The Journal of pharmacology and experimental therapeutics,
