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A method for measurement of gastrin in human antral mucosa or in extragastric tissue has been developed and validated. Tissue gastrin was extracted by boiling followed by homogenization at neutral pH. Extractable gastrin immunoreactivity was measured by radioimmunoassay using an antiserum with equal affinity towards G-17 I, G-17 II, G-34 I and G-34 II molecular forms. Almost all extractable gastrin immunoreactivity was recovered after a single extraction and no significant interference by other peptides and/or substances present in tissue was found. The mean gastrin concentration in antral mucosa of healthy subjects was similar to that observed in duodenal ulcer patients, while patients with type A chronic atrophic gastritis or with antral gastrin cell hyperplasia had mean values significantly higher. Gastrin concentration in all specimens from gastrinoma or its metastases was above the upper limit of the range of control tissue. Measurement of tissue gastrin seems to be a valuable tool in the diagnosis of antral gastrin cell hyperplasia and Zollinger-Ellison syndrome.
P Vezzadini, and
G Bonora, and
P Tomassetti, and
A Favaro, and
R Toni, and
R Ecchia, and
G Labò
January 1975,
Scandinavian journal of gastroenterology,
P Vezzadini, and
G Bonora, and
P Tomassetti, and
A Favaro, and
R Toni, and
R Ecchia, and
G Labò
January 1974,
Verhandlungen der Deutschen Gesellschaft fur Innere Medizin,
P Vezzadini, and
G Bonora, and
P Tomassetti, and
A Favaro, and
R Toni, and
R Ecchia, and
G Labò
August 1975,
American journal of obstetrics and gynecology,
P Vezzadini, and
G Bonora, and
P Tomassetti, and
A Favaro, and
R Toni, and
R Ecchia, and
G Labò
March 1984,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
P Vezzadini, and
G Bonora, and
P Tomassetti, and
A Favaro, and
R Toni, and
R Ecchia, and
G Labò
February 1974,
Gut,
P Vezzadini, and
G Bonora, and
P Tomassetti, and
A Favaro, and
R Toni, and
R Ecchia, and
G Labò
May 1975,
The Journal of physiology,
P Vezzadini, and
G Bonora, and
P Tomassetti, and
A Favaro, and
R Toni, and
R Ecchia, and
G Labò
October 1974,
The Australian journal of experimental biology and medical science,
P Vezzadini, and
G Bonora, and
P Tomassetti, and
A Favaro, and
R Toni, and
R Ecchia, and
G Labò
January 1982,
Laboratornoe delo,
P Vezzadini, and
G Bonora, and
P Tomassetti, and
A Favaro, and
R Toni, and
R Ecchia, and
G Labò
January 1991,
Journal of the Association for Academic Minority Physicians : the official publication of the Association for Academic Minority Physicians,
P Vezzadini, and
G Bonora, and
P Tomassetti, and
A Favaro, and
R Toni, and
R Ecchia, and
G Labò
February 1975,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
