The effect of omeprazole on gastric emptying in patients with duodenal ulcer disease. 1984

M Horowitz, and D J Hetzel, and P J Buckle, and B E Chatterton, and D J Shearman

The effect of a single oral dose of omeprazole (90 mg) on gastric emptying was assessed with a dual isotope scintigraphic technique in eight patients with a history of duodenal ulcer disease. Omeprazole had no significant effect on solid or liquid gastric emptying. The bioavailability (AUC0-2 h) of omeprazole in all patients was greater than that required for total suppression of acid secretion. No adverse clinical or laboratory effects were observed.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009853 Omeprazole A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits an H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS. H 168-68,Omeprazole Magnesium,Omeprazole Sodium,Prilosec,H 168 68,H 16868,Magnesium, Omeprazole,Sodium, Omeprazole
D001794 Blood Pressure PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS. Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D004381 Duodenal Ulcer A PEPTIC ULCER located in the DUODENUM. Curling's Ulcer,Curling Ulcer,Curlings Ulcer,Duodenal Ulcers,Ulcer, Curling,Ulcer, Duodenal,Ulcers, Duodenal
D005746 Gastric Emptying The evacuation of food from the stomach into the duodenum. Emptying, Gastric,Emptyings, Gastric,Gastric Emptyings
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D001562 Benzimidazoles Compounds with a BENZENE fused to IMIDAZOLES.

Related Publications

M Horowitz, and D J Hetzel, and P J Buckle, and B E Chatterton, and D J Shearman
April 1986, Gut,
M Horowitz, and D J Hetzel, and P J Buckle, and B E Chatterton, and D J Shearman
January 1998, Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology,
M Horowitz, and D J Hetzel, and P J Buckle, and B E Chatterton, and D J Shearman
June 1989, The Tohoku journal of experimental medicine,
M Horowitz, and D J Hetzel, and P J Buckle, and B E Chatterton, and D J Shearman
December 1987, Vrachebnoe delo,
M Horowitz, and D J Hetzel, and P J Buckle, and B E Chatterton, and D J Shearman
April 1989, Gut,
M Horowitz, and D J Hetzel, and P J Buckle, and B E Chatterton, and D J Shearman
January 1982, American journal of surgery,
M Horowitz, and D J Hetzel, and P J Buckle, and B E Chatterton, and D J Shearman
July 1982, Digestive diseases and sciences,
M Horowitz, and D J Hetzel, and P J Buckle, and B E Chatterton, and D J Shearman
June 1958, Proceedings of the Royal Society of Medicine,
M Horowitz, and D J Hetzel, and P J Buckle, and B E Chatterton, and D J Shearman
November 1987, Scandinavian journal of gastroenterology,
M Horowitz, and D J Hetzel, and P J Buckle, and B E Chatterton, and D J Shearman
June 1988, Alimentary pharmacology & therapeutics,
Copied contents to your clipboard!