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In order to gain information on the metabolism of dolichol, the rates of excretion of dolichol and dolichyl phosphate were determined in rats maintained on a dolichol-free diet for 10 days. Analysis of fecal samples collected every 48 h yielded mean output values of 9.0 +/- 1.4 and 20.7 +/- 3.0 micrograms/rat/day of dolichol and dolichyl phosphate, respectively. Urinary output rates were 0.56 +/- 0.12 and 0.50 +/- 0.28 microgram/rat/day of dolichol and dolichyl phosphate, respectively. Thus, excretion is one fate of endogenously synthesized dolichol compounds in the rat.
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