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A study was made of variation in the activity of the antioxidant defense system enzymes superoxide dismitase (SOD), glutathione peroxidase, (GP) and glutathione-S-transferase (GT) in the cells of mouse spermatogenic epithelium. The cells were fractionated in the gradient of human serum albumin using the STAPUT system. SOD activity was comparable to that in liver cells, that of GP was one order to magnitude lower, and that of GT one order of magnitude higher than in the liver. Differentiation of spermatogenic cells demonstrated phase variations in the activity of these enzymes, with a maximum seen at the stage of late pachytene spermatocytes. SOD, GP and GT activities were discovered to be reduced in postmeiotic cells (early spermatid fractions) by 2.8-3.5; 1.9-2.3 and 4.2-5.6 times, respectively. That reduction was followed by activation of the enzymes at the late stages of spermiogenesis.
N P Volkova, and
V Z Lankin
January 1974,
Radiobiologiia,
N P Volkova, and
V Z Lankin
January 1976,
Voprosy meditsinskoi khimii,
N P Volkova, and
V Z Lankin
January 1992,
Eksperimental'naia i klinicheskaia farmakologiia,
N P Volkova, and
V Z Lankin
March 1971,
Endocrinology,
N P Volkova, and
V Z Lankin
January 1985,
Ukrainskii biokhimicheskii zhurnal (1978),
N P Volkova, and
V Z Lankin
January 1983,
Development, growth & differentiation,
N P Volkova, and
V Z Lankin
August 1984,
Experimental cell research,
N P Volkova, and
V Z Lankin
January 1986,
Chromosoma,
N P Volkova, and
V Z Lankin
November 1957,
The American journal of anatomy,
N P Volkova, and
V Z Lankin
October 1985,
Endocrinology,
