-transparent.png){kind=logo}
Piperidine is one of pharmacologically active biogenic amines. While two pathways for piperidine production have been reported, little is known about metabolism of the compound. In the present study, piperidine and its hydroxylated, conjugated and unknown metabolites were detected in rat urine by radiochromatographic analysis. Using GC-MS technique, it was confirmed that 3-hydroxypiperidine and 4-hydroxypiperidine are major metabolites of piperidine of either exogenous or endogenous origin. The findings substantiate the existence of a mechanism which inactivates piperidine in the living body, since both metabolites lack the potent pharmacological activities as those induced by piperidine.
Y Okano, and
T Miyata, and
S H Hung, and
T Motoya, and
M Kataoka, and
K Takahama, and
Y Kasé
February 2005,
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences,
Y Okano, and
T Miyata, and
S H Hung, and
T Motoya, and
M Kataoka, and
K Takahama, and
Y Kasé
August 1985,
Biomedical mass spectrometry,
Y Okano, and
T Miyata, and
S H Hung, and
T Motoya, and
M Kataoka, and
K Takahama, and
Y Kasé
September 1983,
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan,
Y Okano, and
T Miyata, and
S H Hung, and
T Motoya, and
M Kataoka, and
K Takahama, and
Y Kasé
January 1975,
Drug metabolism and disposition: the biological fate of chemicals,
Y Okano, and
T Miyata, and
S H Hung, and
T Motoya, and
M Kataoka, and
K Takahama, and
Y Kasé
June 1975,
Research communications in chemical pathology and pharmacology,
Y Okano, and
T Miyata, and
S H Hung, and
T Motoya, and
M Kataoka, and
K Takahama, and
Y Kasé
November 1988,
Biochimica et biophysica acta,
Y Okano, and
T Miyata, and
S H Hung, and
T Motoya, and
M Kataoka, and
K Takahama, and
Y Kasé
February 1983,
Biochemistry international,
Y Okano, and
T Miyata, and
S H Hung, and
T Motoya, and
M Kataoka, and
K Takahama, and
Y Kasé
February 2010,
Forensic science international,
Y Okano, and
T Miyata, and
S H Hung, and
T Motoya, and
M Kataoka, and
K Takahama, and
Y Kasé
September 1972,
Ceskoslovenska farmacie,
Y Okano, and
T Miyata, and
S H Hung, and
T Motoya, and
M Kataoka, and
K Takahama, and
Y Kasé
September 1969,
Journal of agricultural and food chemistry,
