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Effects of L-ascorbate 2-sulfate (AAS) on lipid metabolism and on pathological changes of aorta and visceral organs were investigated in cholesterol fed rabbits, with ascorbic acid (AA) and clofibrate (CPIB) as reference compounds. Administration of AAS (300 and 150 mg/kg) inhibited an increase in the levels of serum total cholesterol, free cholesterol, triglycerides and phospholipids caused by cholesterol feeding. A high dose of AAS prevented an increase of liver weight. An increase in the level of liver cholesterol was inhibited by a high dose of AAS. Both doses of AAS effectively prevented an accumulation of cholesterol in the aorta. The area rate of atheromatous plaque in aorta was less in specimens from both groups of AAS than in those from control I. Pathological changes in intima and media of aorta were milder in specimens from both groups of AAS. Developed of patholoigcal changes in arteries of various organs were prevented with both doses of AAS.
E Hayashi, and
J Yamada, and
M Kunitomo, and
M Terada, and
M Sato
January 1976,
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition,
E Hayashi, and
J Yamada, and
M Kunitomo, and
M Terada, and
M Sato
January 1981,
Sheng li ke xue jin zhan [Progress in physiology],
E Hayashi, and
J Yamada, and
M Kunitomo, and
M Terada, and
M Sato
July 1974,
The Journal of nutrition,
E Hayashi, and
J Yamada, and
M Kunitomo, and
M Terada, and
M Sato
January 1991,
Indian journal of physiology and pharmacology,
E Hayashi, and
J Yamada, and
M Kunitomo, and
M Terada, and
M Sato
January 1968,
The Journal of the Egyptian Medical Association,
E Hayashi, and
J Yamada, and
M Kunitomo, and
M Terada, and
M Sato
December 1959,
The Journal of pharmacology and experimental therapeutics,
E Hayashi, and
J Yamada, and
M Kunitomo, and
M Terada, and
M Sato
January 1979,
Farmakologiia i toksikologiia,
E Hayashi, and
J Yamada, and
M Kunitomo, and
M Terada, and
M Sato
December 2009,
Neurochemistry international,
E Hayashi, and
J Yamada, and
M Kunitomo, and
M Terada, and
M Sato
May 1990,
Archivos de biologia y medicina experimentales,
E Hayashi, and
J Yamada, and
M Kunitomo, and
M Terada, and
M Sato
October 1969,
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan,
