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1-Nitronaphthalene (1-NN) produced respiratory distress and centrilobular liver necrosis in male Sprague-Dawley rats after a single intraperitoneal injection (100 mg kg-1). Microscopic examination of the lungs of rats killed 24 h after the injection revealed a highly selective non-ciliated bronchiolar (Clara) cell necrosis as the only remarkable lesion. Pretreatment of animals with phenobarbital offered complete protection from the respiratory distress induced by 1-NN, but increased the severity of the hepatotoxicity. Pretreatment with SKF-525A protected against 1-NN-induced liver necrosis, but did not alter the incidence or severity of the respiratory distress. Under similar conditions, this pattern of toxicity was not seen with the structural analogue 2-nitronaphthalene.
D E Johnson, and
M G Riley, and
H H Cornish
January 1997,
Toxicology letters,
D E Johnson, and
M G Riley, and
H H Cornish
January 1995,
Archives of toxicology,
D E Johnson, and
M G Riley, and
H H Cornish
September 2006,
Environmental health perspectives,
D E Johnson, and
M G Riley, and
H H Cornish
January 1989,
IARC monographs on the evaluation of carcinogenic risks to humans,
D E Johnson, and
M G Riley, and
H H Cornish
January 1989,
IARC monographs on the evaluation of carcinogenic risks to humans,
D E Johnson, and
M G Riley, and
H H Cornish
October 1993,
Toxicology and applied pharmacology,
D E Johnson, and
M G Riley, and
H H Cornish
April 2015,
Ecotoxicology (London, England),
D E Johnson, and
M G Riley, and
H H Cornish
March 2004,
Inhalation toxicology,
D E Johnson, and
M G Riley, and
H H Cornish
December 1997,
Toxicology and applied pharmacology,
