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Chickens were studied in an attempt to demonstrate correlations between serum lipid levels and peripheral blood lymphocyte (PBL) plasma membrane fluidity and mitogen responsiveness: (a) in the laying hen; (b) during aging; and (c) following dietary manipulation of serum cholesterol of young and aged chickens. The membrane fluidity of PBL from laying hens was significantly greater than that of immature birds. However, no direct correlation was found between serum lipid levels, nor the serum free cholesterol/phospholipid (FC/Pl) mole composition and PBL membrane fluidity in any of the age-groups tested. Likewise, no correlation was found either between serum FC/Pl mole ratio or membrane fluidity and mitogen responsiveness of PBL from birds up to 5 years of age nor was there any evidence for a decline in mitogen responsiveness up to this age. Supplementation of diets with 1% cholesterol induced hypercholesterolemia, mainly in the very low density lipoprotein (VLDL) fraction, but membrane fluidity and mitogen responsiveness remained unaffected.
K N Traill, and
K Ratheiser, and
H Dietrich, and
S Sailer, and
J L Zevenbergen, and
G Wick
January 1962,
Journal of atherosclerosis research,
K N Traill, and
K Ratheiser, and
H Dietrich, and
S Sailer, and
J L Zevenbergen, and
G Wick
January 1979,
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K N Traill, and
K Ratheiser, and
H Dietrich, and
S Sailer, and
J L Zevenbergen, and
G Wick
November 1991,
European journal of immunology,
K N Traill, and
K Ratheiser, and
H Dietrich, and
S Sailer, and
J L Zevenbergen, and
G Wick
August 1981,
Radiation research,
K N Traill, and
K Ratheiser, and
H Dietrich, and
S Sailer, and
J L Zevenbergen, and
G Wick
January 1979,
Cellular and molecular biology, including cyto-enzymology,
K N Traill, and
K Ratheiser, and
H Dietrich, and
S Sailer, and
J L Zevenbergen, and
G Wick
December 1958,
Experientia,
K N Traill, and
K Ratheiser, and
H Dietrich, and
S Sailer, and
J L Zevenbergen, and
G Wick
December 1957,
The Medical journal of Australia,
K N Traill, and
K Ratheiser, and
H Dietrich, and
S Sailer, and
J L Zevenbergen, and
G Wick
March 1959,
The Medical journal of Australia,
K N Traill, and
K Ratheiser, and
H Dietrich, and
S Sailer, and
J L Zevenbergen, and
G Wick
April 1961,
Circulation,
K N Traill, and
K Ratheiser, and
H Dietrich, and
S Sailer, and
J L Zevenbergen, and
G Wick
February 1980,
Mechanisms of ageing and development,
