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The effects of exchange transfusion with an oxygen-carrying resuscitation fluid, Fluosol DA 20% or stroma-free hemoglobin, on the pharmacokinetics of antipyrine, diazepam, penicillin, and sulfamethazine were studied in rats. After transfusion with Fluosol DA 20% or stroma-free hemoglobin the pharmacokinetics of antipyrine, diazepam, and penicillin were unchanged when compared to control animals. After transfusion with Fluosol DA 20%, the t 1/2 of sulfamethazine was increased from 3.15 +/- 0.56 to 7.65 +/- 2.41 hr (p less than 0.05) and the Vd was increased from 60.7 +/- 17.5 to 152 +/- 16 ml (p less than 0.05). In contrast, after transfusion with stroma-free hemoglobin, the AUC of sulfamethazine was decreased from 129 +/- 28 to 80.5 +/- 27.7 micrograms X h X ml-1 (p less than 0.05) and there was an increase in Cl from 12.2 +/- 3.4 to 20.2 +/- 6.0 ml X h-1 (p less than 0.05) and Vd from 60.1 +/- 11.8 to 132 +/- 49 ml (p less than 0.05). The reason for these alterations is not clear. Fluosol DA 20% and stroma-free hemoglobin may alter the acetylation of sulfamethazine.
J M Kemner, and
W R Snodgrass, and
S E Worley, and
G R Hodges, and
S Melethil, and
C E Hignite, and
C Tschanz
May 1995,
Critical care medicine,
J M Kemner, and
W R Snodgrass, and
S E Worley, and
G R Hodges, and
S Melethil, and
C E Hignite, and
C Tschanz
December 1984,
Antimicrobial agents and chemotherapy,
J M Kemner, and
W R Snodgrass, and
S E Worley, and
G R Hodges, and
S Melethil, and
C E Hignite, and
C Tschanz
September 1991,
Journal of veterinary pharmacology and therapeutics,
J M Kemner, and
W R Snodgrass, and
S E Worley, and
G R Hodges, and
S Melethil, and
C E Hignite, and
C Tschanz
April 1985,
The Journal of pharmacology and experimental therapeutics,
J M Kemner, and
W R Snodgrass, and
S E Worley, and
G R Hodges, and
S Melethil, and
C E Hignite, and
C Tschanz
November 1990,
Antimicrobial agents and chemotherapy,
J M Kemner, and
W R Snodgrass, and
S E Worley, and
G R Hodges, and
S Melethil, and
C E Hignite, and
C Tschanz
November 1989,
The Journal of pharmacology and experimental therapeutics,
J M Kemner, and
W R Snodgrass, and
S E Worley, and
G R Hodges, and
S Melethil, and
C E Hignite, and
C Tschanz
July 1993,
Biulleten' eksperimental'noi biologii i meditsiny,
J M Kemner, and
W R Snodgrass, and
S E Worley, and
G R Hodges, and
S Melethil, and
C E Hignite, and
C Tschanz
April 1992,
Biulleten' eksperimental'noi biologii i meditsiny,
J M Kemner, and
W R Snodgrass, and
S E Worley, and
G R Hodges, and
S Melethil, and
C E Hignite, and
C Tschanz
August 1987,
Clinical pharmacology and therapeutics,
J M Kemner, and
W R Snodgrass, and
S E Worley, and
G R Hodges, and
S Melethil, and
C E Hignite, and
C Tschanz
June 1993,
Clinical pharmacy,
