Primary synovial chondrometaplasia. Histologic variations in the structure of metaplastic nodules. 1984

P Baunsgaard, and B B Nielsen

Eight cases of primary synovial chondrometaplasia have been evaluated with respect to 1) number of metaplastic nodules, 2) their location in relation to the surface of the synovium, 3) the histochemical composition of the matrix of the nodules; number of nodules with 4) cystic degeneration, 5) osteoclastic/chondroclastic activity at the margin, 6) invasion of connective tissue and 7) calcification and/or ossification. Furthermore, the pleomorphism and hyperchromatism of the chondroid cells and their nuclei and number of mitoses were evaluated. The number of metaplastic nodules varied greatly, from a few to more than a hundred. Most nodules were located at the level of the original synovial surface or in the pedunculated prominences. Histochemically, two types of nodules were found and in about equal numbers. Connective tissue invasion, calcification and ossification were the most frequent changes; whereas cystic degeneration, which has not been described before, was the rarest. Only one of the cases showed all the different changes, and these within a considerable number of the nodules. Variation of the chondroid cells and their nuclei was considered as an expression of degenerative changes, and mitoses were not found. Two of the cases had a tumor-like accumulation of metaplastic nodules.

UI MeSH Term Description Entries
D007719 Knee Joint A synovial hinge connection formed between the bones of the FEMUR; TIBIA; and PATELLA. Superior Tibiofibular Joint,Joint, Knee,Joint, Superior Tibiofibular,Knee Joints,Superior Tibiofibular Joints,Tibiofibular Joint, Superior
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D002812 Chondroma A benign neoplasm derived from mesodermal cells that form cartilage. It may remain within the substance of a cartilage or bone (true chondroma or enchondroma) or may develop on the surface of a cartilage (ecchondroma or ecchondrosis). (Dorland, 27th ed; Stedman, 25th ed) Enchondroma,Chondromas,Enchondromas
D005260 Female Females
D005385 Fingers Four or five slender jointed digits in humans and primates, attached to each HAND. Finger
D006621 Hip Joint The joint that is formed by the articulation of the head of FEMUR and the ACETABULUM of the PELVIS. Acetabulofemoral Joint,Acetabulofemoral Joints,Hip Joints,Joint, Acetabulofemoral,Joint, Hip,Joints, Acetabulofemoral,Joints, Hip
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults

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