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It has been reported recently that 5-amino-34,4'-bipyridine-6(1H)-one is a new positive inotropic agent that appears to offer significant advantages over the cardiac glycosides. The effects of this agent were studied in a modified heart-lung preparation which allows the measurement of coronary flow and oxygen consumption in addition to a controlled study of cardiac contractility. In two models of cardiac insufficiency the administration of 5 mg amrinone caused a marked increase in cardiac output and a considerable decrease in left atrial pressure with complete reversal of the failure. In addition, the drug produces a 78% increase in coronary flow. Amrinone produces in these preparations a proportionally larger increase in cardiac output than in oxygen consumption, thus this agent increases cardiac efficiency. These results suggest that this new compound could be very useful in the treatment of cardiac insufficiency in congestive heart failure.
L Bárcenas, and
E Kabela
July 1988,
Der Anaesthesist,
L Bárcenas, and
E Kabela
December 1978,
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L Bárcenas, and
E Kabela
May 1984,
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L Bárcenas, and
E Kabela
January 1979,
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L Bárcenas, and
E Kabela
October 1987,
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L Bárcenas, and
E Kabela
July 1982,
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L Bárcenas, and
E Kabela
March 1974,
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L Bárcenas, and
E Kabela
December 1981,
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L Bárcenas, and
E Kabela
January 1984,
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L Bárcenas, and
E Kabela
December 1987,
Circulation research,
