Dye-sensitized photo-oxidation of pig kidney Dopa decarboxylase. 1984

A Pasqua, and P Dominici, and S M Murgia, and A Poletti, and C Borri Voltattorni

The effects of irradiation of pig kidney Dopa decarboxylase by visible light absorbed by the intrinsic chromophore, pyridoxal-P, and by the externally added dyes, pyridoxal-P or proflavin, have been studied. In all cases inactivation was observed, even though to different extens, which seemed to be essentially correlated to tryptophanyl residues photodestruction. Kinetics of inactivation and oxidation of these amino acid residues revealed the presence of two distinct groups of tryptophan residues with different photooxidation rate constants. A different role for these classes of residues in the structure and function of Dopa decarboxylase has been suggested.

UI MeSH Term Description Entries
D007668 Kidney Body organ that filters blood for the secretion of URINE and that regulates ion concentrations. Kidneys
D008027 Light That portion of the electromagnetic spectrum in the visible, ultraviolet, and infrared range. Light, Visible,Photoradiation,Radiation, Visible,Visible Radiation,Photoradiations,Radiations, Visible,Visible Light,Visible Radiations
D010084 Oxidation-Reduction A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471). Redox,Oxidation Reduction
D010777 Photochemistry A branch of physical chemistry which studies chemical reactions, isomerization and physical behavior that may occur under the influence of visible and/or ultraviolet light. Photochemistries
D011370 Proflavine Topical antiseptic used mainly in wound dressings. 3,6-Diamino Acridine,3,6-Diaminoacridine,Proflavin,Proflavine Hemisulfate,3,6 Diamino Acridine,3,6 Diaminoacridine,Acridine, 3,6-Diamino,Hemisulfate, Proflavine
D011732 Pyridoxal Phosphate This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE). Pyridoxal 5-Phosphate,Pyridoxal-P,Phosphate, Pyridoxal,Pyridoxal 5 Phosphate,Pyridoxal P
D004296 Dopa Decarboxylase One of the AROMATIC-L-AMINO-ACID DECARBOXYLASES, this enzyme is responsible for the conversion of DOPA to DOPAMINE. It is of clinical importance in the treatment of Parkinson's disease. Decarboxylase, Dopa
D004396 Coloring Agents Chemicals and substances that impart color including soluble dyes and insoluble pigments. They are used in INKS; PAINTS; and as INDICATORS AND REAGENTS. Coloring Agent,Dye,Dyes,Organic Pigment,Stain,Stains,Tissue Stain,Tissue Stains,Organic Pigments,Pigments, Inorganic,Agent, Coloring,Inorganic Pigments,Pigment, Organic,Pigments, Organic,Stain, Tissue,Stains, Tissue
D000596 Amino Acids Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins. Amino Acid,Acid, Amino,Acids, Amino
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

Related Publications

A Pasqua, and P Dominici, and S M Murgia, and A Poletti, and C Borri Voltattorni
January 1985, The Biochemical journal,
A Pasqua, and P Dominici, and S M Murgia, and A Poletti, and C Borri Voltattorni
January 1969, International journal of protein research,
A Pasqua, and P Dominici, and S M Murgia, and A Poletti, and C Borri Voltattorni
July 1970, Photochemistry and photobiology,
A Pasqua, and P Dominici, and S M Murgia, and A Poletti, and C Borri Voltattorni
January 1990, Annals of the New York Academy of Sciences,
A Pasqua, and P Dominici, and S M Murgia, and A Poletti, and C Borri Voltattorni
January 1984, Immunological communications,
A Pasqua, and P Dominici, and S M Murgia, and A Poletti, and C Borri Voltattorni
January 1995, Biochimie,
A Pasqua, and P Dominici, and S M Murgia, and A Poletti, and C Borri Voltattorni
December 1986, Archives of biochemistry and biophysics,
A Pasqua, and P Dominici, and S M Murgia, and A Poletti, and C Borri Voltattorni
September 1977, Biochemical and biophysical research communications,
A Pasqua, and P Dominici, and S M Murgia, and A Poletti, and C Borri Voltattorni
April 1992, Journal of molecular biology,
A Pasqua, and P Dominici, and S M Murgia, and A Poletti, and C Borri Voltattorni
January 1981, Life sciences,
Copied contents to your clipboard!