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In a retrospective study we determined the relation between estrogen receptors and the response rate to cytotoxic chemotherapy in 70 patients with metastatic breast cancer. Thirty-four of 45 patients with low or absent estrogen-receptor values (less than 10 fmol per milligram of cytoplasmic protein) had objective responses to chemotherapy, whereas only three of 25 patients with higher values (greater than 10 fmol per milligram of cytoplasmic protein) responded (P less than 0.0001). There were no statistically significant differences between the two groups in age, menopausal status, disease-free interval, Karnofsky index or prior therapy. Differences in sites of involvement or type of chemotherapy did not account for the increased response rate in receptor-negative patients. We conclude that estrogen-receptor values are an important predictor of response to cytotoxic chemotherapy in metastatic breast cancer.
M E Lippman, and
J C Allegra, and
E B Thompson, and
R Simon, and
A Barlock, and
L Green, and
K K Huff, and
H M Do, and
S C Aitken, and
R Warren
December 1980,
Cancer,
M E Lippman, and
J C Allegra, and
E B Thompson, and
R Simon, and
A Barlock, and
L Green, and
K K Huff, and
H M Do, and
S C Aitken, and
R Warren
December 1980,
Cancer,
M E Lippman, and
J C Allegra, and
E B Thompson, and
R Simon, and
A Barlock, and
L Green, and
K K Huff, and
H M Do, and
S C Aitken, and
R Warren
September 1978,
The New England journal of medicine,
M E Lippman, and
J C Allegra, and
E B Thompson, and
R Simon, and
A Barlock, and
L Green, and
K K Huff, and
H M Do, and
S C Aitken, and
R Warren
February 1982,
Tumori,
M E Lippman, and
J C Allegra, and
E B Thompson, and
R Simon, and
A Barlock, and
L Green, and
K K Huff, and
H M Do, and
S C Aitken, and
R Warren
January 1980,
Cancer chemotherapy and pharmacology,
M E Lippman, and
J C Allegra, and
E B Thompson, and
R Simon, and
A Barlock, and
L Green, and
K K Huff, and
H M Do, and
S C Aitken, and
R Warren
June 1980,
Nihon Gan Chiryo Gakkai shi,
M E Lippman, and
J C Allegra, and
E B Thompson, and
R Simon, and
A Barlock, and
L Green, and
K K Huff, and
H M Do, and
S C Aitken, and
R Warren
January 1979,
Cancer clinical trials,
M E Lippman, and
J C Allegra, and
E B Thompson, and
R Simon, and
A Barlock, and
L Green, and
K K Huff, and
H M Do, and
S C Aitken, and
R Warren
April 1989,
Tumori,
M E Lippman, and
J C Allegra, and
E B Thompson, and
R Simon, and
A Barlock, and
L Green, and
K K Huff, and
H M Do, and
S C Aitken, and
R Warren
April 1984,
Cancer treatment reports,
M E Lippman, and
J C Allegra, and
E B Thompson, and
R Simon, and
A Barlock, and
L Green, and
K K Huff, and
H M Do, and
S C Aitken, and
R Warren
July 1989,
Cancer,
