Biomaterial Database

[Experimental cerebral infarction. Part 1: Production of thalamus infarction model in dogs (author's transl)]. 1978

T Yoshimoto, and T Sakamoto, and J Suzuki

Difficulties in producing temporary cerebral ischemia in experimental animals have delayed the study on the prevention and treatment of cerebral infarction. Although occlusion of the middle cerebral artery in dog proved to be fruitless, we eventually succeeded in producing focal cerebral infarction by temporary occlusions of brain arteries. Infarction confined to the anterior portion of the thalamus was obtained by simultaneous occlusion of four arteries for 60 or 120 minutes: internal carotid, anterior cerebral, middle cerebral and posterior communicating arteries. This experimental model in dogs is unique, since a marked infarction can be seen in high frequency, and the dogs can be managed for sufficient periods after temporary clipping. Consequently, it is possible to investigate cerebral infarction not only from the pathophysiological viewpoint, but also for its prevention and treatment.

UI	MeSH Term	Description	Entries
D008722	Methods	A series of steps taken in order to conduct research.	Techniques,Methodological Studies,Methodological Study,Procedures,Studies, Methodological,Study, Methodological,Method,Procedure,Technique
D002542	Intracranial Embolism and Thrombosis	Embolism or thrombosis involving blood vessels which supply intracranial structures. Emboli may originate from extracranial or intracranial sources. Thrombosis may occur in arterial or venous structures.	Brain Embolism and Thrombosis,Cerebral Embolism and Thrombosis,Embolism and Thrombosis, Brain
D004195	Disease Models, Animal	Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	Animal Disease Model,Animal Disease Models,Disease Model, Animal
D004285	Dogs	The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)	Canis familiaris,Dog
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013788	Thalamus	Paired bodies containing mostly GRAY MATTER and forming part of the lateral wall of the THIRD VENTRICLE of the brain.	Thalamencephalon,Thalamencephalons