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The effect of steroids on the repair of a corneal endothelial defect in rabbits was studied by in vivo and by organ culture experiments. A standard 4 mm defect was produced by transcorneal freezing. The situation after 2, 3, and 4 days was studied by scanning electron microscopy. Preliminary experiments demonstrated that topical eye treatment influenced on the repair process of the untreated, contralateral eye. The preservants of commercial eye drops caused delayed healing in organ culture. These effects were excluded from the control experiments. Topical eye treatment with steroid eye drops for 3 days caused a one day delay in the repair process. In culture medium, delayed repair was found at hydrocortisone concentrations greater than or equal to 0.125 mg/ml. The visible influence of hydrocortisone increased with the concentration in the range examined, between 0.05 mg/ml and 1 mg/ml.
E G Olsen, and
M Davanger
January 1974,
Investigative ophthalmology,
E G Olsen, and
M Davanger
August 1972,
Investigative ophthalmology,
E G Olsen, and
M Davanger
May 1958,
A.M.A. archives of ophthalmology,
E G Olsen, and
M Davanger
December 2008,
Cornea,
E G Olsen, and
M Davanger
January 1983,
Japanese journal of ophthalmology,
E G Olsen, and
M Davanger
May 1997,
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie,
E G Olsen, and
M Davanger
August 2000,
Archivos de la Sociedad Espanola de Oftalmologia,
E G Olsen, and
M Davanger
January 1989,
Ophthalmic research,
E G Olsen, and
M Davanger
January 1998,
Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde,
E G Olsen, and
M Davanger
October 1980,
Journal - American Intra-Ocular Implant Society,
