Biomaterial Database

Mesonephric excretory function related to its influence on differentiation of fetal gonads. 1984

J Grinsted, and L Aagesen

The mammalian intermediate fetal kidney, the mesonephros, is known in different species to excrete body waste products during a limited period of fetal life. Recently, the mesonephros and its derivatives have been shown to influence gonadal functions in several ways. Thus, the mesonephric cells are responsible for regulating the onset of meiosis in different mammals by the secretion of two substances, a meiosis-inducing substance (MIS) and a meiosis-preventing substance (MPS). In this paper, the relation between mesonephric kidney function and its influence on the gonads is reviewed through literature studies. It seems that cessation of mesonephric excretion precedes onset of meiosis in the ovary in different species. It is suggested that the mesonephric renal function interferes with synthesis and/or secretion of MIS or that the excreted products may interfere with the responsiveness to MIS of the germ cells.

UI	MeSH Term	Description	Entries
D008322	Mammals	Warm-blooded vertebrate animals belonging to the class Mammalia, including all that possess hair and suckle their young.	Mammalia,Mammal
D008650	Mesonephros	One of a pair of excretory organs (mesonephroi) which grows caudally to the first pair (PRONEPHROI) during development. Mesonephroi are the permanent kidneys in adult amphibians and fish. In higher vertebrates, proneprhoi and most of mesonephroi degenerate with the appearance of metanephroi. The remaining ducts become WOLFFIAN DUCTS.	Wolffian Body,Mesonephroi,Body, Wolffian
D005333	Fetus	The unborn young of a viviparous mammal, in the postembryonic period, after the major structures have been outlined. In humans, the unborn young from the end of the eighth week after CONCEPTION until BIRTH, as distinguished from the earlier EMBRYO, MAMMALIAN.	Fetal Structures,Fetal Tissue,Fetuses,Mummified Fetus,Retained Fetus,Fetal Structure,Fetal Tissues,Fetus, Mummified,Fetus, Retained,Structure, Fetal,Structures, Fetal,Tissue, Fetal,Tissues, Fetal
D006066	Gonads	The gamete-producing glands, OVARY or TESTIS.	Gonad
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012733	Sex Differentiation	The process in developing sex- or gender-specific tissue, organ, or function after SEX DETERMINATION PROCESSES have set the sex of the GONADS. Major areas of sex differentiation occur in the reproductive tract (GENITALIA) and the brain.	Differentiation, Sex,Sexual Differentiation,Differentiation, Sexual
D013045	Species Specificity	The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.	Species Specificities,Specificities, Species,Specificity, Species