Occupational exposure to chlorophenates: toxicology and respiratory effects. 1984

V Embree, and D A Enarson, and M Chan-Yeung, and A DyBuncio, and R Dennis, and J Leach

We have identified 71 chlorophenate-exposed sawmill workers as part of a group undergoing an extensive health and environmental evaluation in a pulp mill. We have compared this group with a group (351) with no physical proximity to the area in which chlorophenates were used. We demonstrated a gradient of exposure from 230 ppb in urine and 919 ppb in serum for those directly handling the contaminated wood, to 139 ppb in urine and 354 ppb in serum for those working in the area but not in manual contact as compared with serum levels of 84 ppb in the unexposed group. We noted that the bulk chemical was primarily in the tetrachloro-form but the serum levels contained more pentachlorophenate. The urine proportions were intermediate, approximating the bulk chemical proportions at the lower levels of exposure. We did not find an excess prevalence of respiratory symptoms or spirometric abnormalities which could be explained by the chlorophenate exposure.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009784 Occupational Diseases Diseases caused by factors involved in one's employment. Diseases, Occupational,Occupational Illnesses,Disease, Occupational,Illnesse, Occupational,Illnesses, Occupational,Occupational Disease,Occupational Illnesse
D010209 Paper Thin sheets made from wood pulp and other fibrous substances, used for writing, drawing, printing, image duplication or wrapping. Papers
D011795 Surveys and Questionnaires Collections of data obtained from voluntary subjects. The information usually takes the form of answers to questions, or suggestions. Community Survey,Nonrespondent,Questionnaire,Questionnaires,Respondent,Survey,Survey Method,Survey Methods,Surveys,Baseline Survey,Community Surveys,Methodology, Survey,Nonrespondents,Questionnaire Design,Randomized Response Technique,Repeated Rounds of Survey,Respondents,Survey Methodology,Baseline Surveys,Design, Questionnaire,Designs, Questionnaire,Methods, Survey,Questionnaire Designs,Questionnaires and Surveys,Randomized Response Techniques,Response Technique, Randomized,Response Techniques, Randomized,Survey, Baseline,Survey, Community,Surveys, Baseline,Surveys, Community,Techniques, Randomized Response
D012140 Respiratory Tract Diseases Diseases involving the RESPIRATORY SYSTEM. Respiratory Diseases,Respiratory System Diseases,Disease, Respiratory System,Disease, Respiratory Tract,Respiratory System Disease,Respiratory Tract Disease
D002733 Chlorophenols Phenols substituted with one or more chlorine atoms in any position. Chlorophenol,Hydroxychlorobenzenes
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000395 Air Pollutants, Occupational Toxic air-borne matter related to work performed They are usually produced by the specific nature of the occupation. Occupational Air Pollutants,Pollutants, Occupational Air

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