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Tritiated rifaximin was administered in a single oral dose of 10 mg/kg (specific activity 8.998 microCi/mg) and 100 mg/kg (specific activity 0.786 microCi/mg) to rats. After treatment, at fixed times, the animals were sacrificed and the radioactivity in plasma, urine, feces, and in the principal organs and tissues was measured. The radioactivity present in the feces of the two groups of rats was more than 95% of the administered dose, while the amounts found in the urine ranged between 1.15% and 1.5% of the dose. In the plasma and tissues the radioactivity levels were very low. This evidence confirmed the scanty gastroenteric absorption of L/105. Furthermore, as the radioactivity levels maintained almost the same value during the trial, there was the possibility that the amounts found were in part due to isotopic exchange between tritium of 3H-L/105 and hydrogen of water.
L Cellai, and
M Colosimo, and
E Marchi, and
A P Venturini, and
G Zanolo
June 1986,
Chemioterapia : international journal of the Mediterranean Society of Chemotherapy,
L Cellai, and
M Colosimo, and
E Marchi, and
A P Venturini, and
G Zanolo
January 1994,
International journal of clinical pharmacology research,
L Cellai, and
M Colosimo, and
E Marchi, and
A P Venturini, and
G Zanolo
January 1983,
Chemotherapy,
L Cellai, and
M Colosimo, and
E Marchi, and
A P Venturini, and
G Zanolo
January 1987,
Drugs under experimental and clinical research,
L Cellai, and
M Colosimo, and
E Marchi, and
A P Venturini, and
G Zanolo
January 1985,
Arzneimittel-Forschung,
L Cellai, and
M Colosimo, and
E Marchi, and
A P Venturini, and
G Zanolo
August 1986,
Chemioterapia : international journal of the Mediterranean Society of Chemotherapy,
L Cellai, and
M Colosimo, and
E Marchi, and
A P Venturini, and
G Zanolo
January 1990,
Therapie,
L Cellai, and
M Colosimo, and
E Marchi, and
A P Venturini, and
G Zanolo
July 1983,
International journal of clinical pharmacology, therapy, and toxicology,
L Cellai, and
M Colosimo, and
E Marchi, and
A P Venturini, and
G Zanolo
January 2005,
Reviews in gastroenterological disorders,
L Cellai, and
M Colosimo, and
E Marchi, and
A P Venturini, and
G Zanolo
January 1976,
Arzneimittel-Forschung,
