-transparent.png){kind=logo}
To investigate the extra-hepatic organs metabolism of trichloroethylene, the extra-hepatic circulation in dogs was established by operating on the portal vein-right femoral vein bypass and other locations. These dogs were exposed for one hour to trichloroethylene at concentrations of 700 ppm. Metabolite (trichloroethanol (F-TCE), trichloroacetic acid (TCA) and total trichloroethanol (T-TCE) changes in serum and urine were measured from the beginning of exposure until one hour after termination, and compared with previous data as control. The following results were obtained. This operation method gave a very slight invasion on dogs. About two hours after the operation, no abnormal findings were observed clinically or physiologically. This method was considered to be one of the best for study of the metabolism of chemical substances in the extra-hepatic organs of dogs. The produced ratios of F-TCE, TCA and T-TCE in extrahepatic organs were about 60, 10 and 30% exposure to trichloroethylene at 700 ppm, respectively.
T Hobara, and
H Kobayashi, and
E Higashihara, and
T Kawamoto, and
S Iwamoto, and
T Sakai
January 1959,
Archiv fur Gewerbepathologie und Gewerbehygiene,
T Hobara, and
H Kobayashi, and
E Higashihara, and
T Kawamoto, and
S Iwamoto, and
T Sakai
October 1978,
Food and cosmetics toxicology,
T Hobara, and
H Kobayashi, and
E Higashihara, and
T Kawamoto, and
S Iwamoto, and
T Sakai
May 1989,
British journal of clinical pharmacology,
T Hobara, and
H Kobayashi, and
E Higashihara, and
T Kawamoto, and
S Iwamoto, and
T Sakai
December 1978,
Gastroenterology,
T Hobara, and
H Kobayashi, and
E Higashihara, and
T Kawamoto, and
S Iwamoto, and
T Sakai
July 1956,
The Journal of biological chemistry,
T Hobara, and
H Kobayashi, and
E Higashihara, and
T Kawamoto, and
S Iwamoto, and
T Sakai
January 1968,
Scandinavian journal of gastroenterology,
T Hobara, and
H Kobayashi, and
E Higashihara, and
T Kawamoto, and
S Iwamoto, and
T Sakai
January 1970,
Eksperimental'naia khirurgiia i anesteziologiia,
T Hobara, and
H Kobayashi, and
E Higashihara, and
T Kawamoto, and
S Iwamoto, and
T Sakai
November 1980,
Biochemical pharmacology,
T Hobara, and
H Kobayashi, and
E Higashihara, and
T Kawamoto, and
S Iwamoto, and
T Sakai
May 2000,
Environmental health perspectives,
T Hobara, and
H Kobayashi, and
E Higashihara, and
T Kawamoto, and
S Iwamoto, and
T Sakai
January 1964,
Archives des maladies professionnelles de medecine du travail et de securite sociale,
