Biomaterial Database

[Erythrocyte protoporphyrin IX in occupational exposure to asbestos]. 1984

A Stankiewicz

Analysis of the dependence of protoporphyrin IX in erythrocytes upon non-exposed populations age. The study was performed in 246 persons (104 women and 142 men) who were not occupationally exposed to toxic agents. The women were aged 19-72, the men 19-76. The mean concentrations of protoporphyrin IX for those groups do not differ significantly. To test the dependence of protoporphyrin IX concentration upon age, the women and men were divided into three age subgroups: under 30, 31-40, and over 40. The statistical analysis indicated different distribution of mean protoporphyrin IX concentrations at those age intervals in both test groups, no significant difference between those values being found. Effects of asbestos upon protoporphyrin IX concentrations in erythrocytes in occupational exposure. Sixty three persons were examined (27 women and 36 men), workers of the Plant of Asbestos Seals and Products, "POLONIT", Lódź. The exposure lasted 1-35 years. Age intervals: women 25-64, men 25-63. The estimated mean protoporphyrin IX concentrations both for women (51.2 mg%) and men (47.6 mg%) differ significantly from the mean values of relevant control groups (39.3 and 37.6). In addition, ferrum concentration in serum and hemoglobin concentration in blood in the mentioned groups were analysed. All the findings were within the physiological values.

UI	MeSH Term	Description	Entries
D007501	Iron	A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.	Iron-56,Iron 56
D008107	Liver Diseases	Pathological processes of the LIVER.	Liver Dysfunction,Disease, Liver,Diseases, Liver,Dysfunction, Liver,Dysfunctions, Liver,Liver Disease,Liver Dysfunctions
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D011164	Porphyrias	A diverse group of metabolic diseases characterized by errors in the biosynthetic pathway of HEME in the LIVER, the BONE MARROW, or both. They are classified by the deficiency of specific enzymes, the tissue site of enzyme defect, or the clinical features that include neurological (acute) or cutaneous (skin lesions). Porphyrias can be hereditary or acquired as a result of toxicity to the hepatic or erythropoietic marrow tissues.	Porphyria,Porphyrin Disorder,Disorder, Porphyrin,Disorders, Porphyrin,Porphyrin Disorders
D011166	Porphyrins	A group of compounds containing the porphin structure, four pyrrole rings connected by methine bridges in a cyclic configuration to which a variety of side chains are attached. The nature of the side chain is indicated by a prefix, as uroporphyrin, hematoporphyrin, etc. The porphyrins, in combination with iron, form the heme component in biologically significant compounds such as hemoglobin and myoglobin.	Porphyrin
D011524	Protoporphyrins	Porphyrins with four methyl, two vinyl, and two propionic acid side chains attached to the pyrrole rings. Protoporphyrin IX occurs in hemoglobin, myoglobin, and most of the cytochromes.
D004912	Erythrocytes	Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.	Blood Cells, Red,Blood Corpuscles, Red,Red Blood Cells,Red Blood Corpuscles,Blood Cell, Red,Blood Corpuscle, Red,Erythrocyte,Red Blood Cell,Red Blood Corpuscle
D005260	Female		Females
D006454	Hemoglobins	The oxygen-carrying proteins of ERYTHROCYTES. They are found in all vertebrates and some invertebrates. The number of globin subunits in the hemoglobin quaternary structure differs between species. Structures range from monomeric to a variety of multimeric arrangements.	Eryhem,Ferrous Hemoglobin,Hemoglobin,Hemoglobin, Ferrous