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Three sisters with a rare complementation group of classical xeroderma pigmentosum (XP-E) are presented. The patients developed sun-sensitivity and dyspigmentation between the ages of 6 and 9 years and UV-induced skin tumors between 16 and 20. All malignant skin tumors were basal cell carcinomas; no other skin tumors have been diagnosed so far. Measurement of UV-induced unscheduled DNA synthesis in cultivated fibroblasts showed very high residual repair levels: 60 to 70% of controls. In fusion experiments with representative cell strains complementation was found with the XP-A, B, C, D and G complementation group but it was absent when the fibroblasts under study were fused with XP-E group fibroblasts. Thus the cell lines were assigned to the XP complementation group E.
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E Fischer, and
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E Fischer, and
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E G Jung
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Mutation research,
E Fischer, and
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E G Jung
January 1992,
Mutation research,
E Fischer, and
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E G Jung
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E Fischer, and
U W Schnyder, and
E G Jung
January 1985,
Mutation research,
E Fischer, and
U W Schnyder, and
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May 1985,
Nihon Hifuka Gakkai zasshi. The Japanese journal of dermatology,
E Fischer, and
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E Fischer, and
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June 1987,
The British journal of dermatology,
E Fischer, and
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E G Jung
January 1974,
Mutation research,
