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Synthesis of 2-carbalkoxyamino-5(6)-(1-substituted piperazin-4-yl/piperazin-4-ylcarbonyl)benzimidazoles and related compounds as potential anthelmintics. 1984

S Abuzar, and S Sharma

A number of 1,4-di-(3,4-disubstituted benzoyl)piperazines (3-6), 1-(3,4-disubstituted benzoyl)-4-(3,4-disubstituted phenyl)piperazines (9-11), 1,4-di-(2-carbalkoxyaminobenzimidazol-5(6)-yl-carbonyl)piperazines (12, 13), 1-(2-carbalkoxyaminobenzimidazol-5(6)- ylcarbonyl)-4-(2-carbalkoxyaminobenzimidazol-5(6)-yl) piperazines (14, 15) and 1-(2-carbalkoxyaminobenzimidazol-5(6)-yl)-4-(N,N- dicarbalkoxyamidino)piperazines (17, 18) have been synthesized and their anthelmintic activity is reported.

UI MeSH Term Description Entries
D010879 Piperazines Compounds that are derived from PIPERAZINE.
D006224 Cricetinae A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS. Cricetus,Hamsters,Hamster
D006925 Hymenolepiasis Infection with tapeworms of the genus Hymenolepis. Hymenolepis Infection,Hymenolepiases,Hymenolepis Infections,Infection, Hymenolepis,Infections, Hymenolepis
D000724 Ancylostomiasis Infection of humans or animals with hookworms of the genus ANCYLOSTOMA. Characteristics include anemia, dyspepsia, eosinophilia, and abdominal swelling. Ancylostomiases
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000871 Anthelmintics Agents that kill parasitic worms. They are used therapeutically in the treatment of HELMINTHIASIS in man and animal. Anthelmintic,Antihelmintic,Vermifuge,Vermifuges,Antihelmintics
D001562 Benzimidazoles Compounds with a BENZENE fused to IMIDAZOLES.
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

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