Biomaterial Database

The effect of blood O2 affinity on the efficiency of O2 transport in blood at hypoxic hypoxia. 1984

Z Turek, and F Kreuzer, and P Scotto, and K Rakusan

An index of the efficiency of O2 transport in blood and delivery to tissues, the capacitance coefficient beta, was theoretically analyzed as a function of the position of the blood O2 dissociation curve (ODC). The P50 at which beta reaches its maximum is high at normoxia and decreases with lowering the ambient PO2. At very deep hypoxia this value becomes lower than the normal P50 of human blood. An increase of blood O2 capacity enlarges beta, particularly at deep hypoxia, and also increases the P50 at which maximal beta is reached. Changes of (a-v)O2 have ambivalent effects, depending on both P50 and PaO2. The capacitance coefficient beta was further calculated as a function of PaO2 at three values of P50, simulating the effect of a shift of the ODC. The capacitance coefficient is several times higher at deep hypoxia than at normoxia at all values of P50 used. A shift of the ODC to the left results in a moderate decrease of beta at mild hypoxia but in a large increase at severe hypoxia; a shift to the right has a reverse effect.

UI	MeSH Term	Description	Entries
D008954	Models, Biological	Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.	Biological Model,Biological Models,Model, Biological,Models, Biologic,Biologic Model,Biologic Models,Model, Biologic
D010100	Oxygen	An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.	Dioxygen,Oxygen-16,Oxygen 16
D010101	Oxygen Consumption	The rate at which oxygen is used by a tissue; microliters of oxygen STPD used per milligram of tissue per hour; the rate at which oxygen enters the blood from alveolar gas, equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body. (Stedman, 25th ed, p346)	Consumption, Oxygen,Consumptions, Oxygen,Oxygen Consumptions
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D000860	Hypoxia	Sub-optimal OXYGEN levels in the ambient air of living organisms.	Anoxia,Oxygen Deficiency,Anoxemia,Deficiency, Oxygen,Hypoxemia,Deficiencies, Oxygen,Oxygen Deficiencies
D001693	Biological Transport, Active	The movement of materials across cell membranes and epithelial layers against an electrochemical gradient, requiring the expenditure of metabolic energy.	Active Transport,Uphill Transport,Active Biological Transport,Biologic Transport, Active,Transport, Active Biological,Active Biologic Transport,Transport, Active,Transport, Active Biologic,Transport, Uphill