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To investigate the influence of hormones on the process of cellular differentiation the growth and differentiation of a transplantable tumour, induced by inoculation of pluripotent mouse embryonal carcinoma (EC) cells have been studied in athymic nude mice and, normal and hypopituitary Snell dwarf mice. All athymic nude mice developed tumours independent of the numbers of cells inoculated. In contrast, the tumour percentage in normal Snell mice was lower, showing a dose-dependent increase of takes. In dwarfs tumour percentage was comparable with that observed in normal Snell mice. The morphological differentiation of teratocarcinomas grown in athymic nude mice, normal and dwarfed Snell mice shows derivatives of all three germ layers next to undifferentiated embryonal carcinoma cells. This suggests that the pituitary hormonal deficiencies of the dwarfs (growth hormone, thyroid stimulating hormone and prolactin) did not influence the tumour induction nor the development of the different tissues present in this type of tumour.
A W van der Kamp, and
S C van Buul-Offers, and
E J Roza-de Jongh, and
M Feijlbrief, and
J Branger, and
E van Rongen
February 1987,
Experimental cell research,
A W van der Kamp, and
S C van Buul-Offers, and
E J Roza-de Jongh, and
M Feijlbrief, and
J Branger, and
E van Rongen
July 1987,
Acta endocrinologica,
A W van der Kamp, and
S C van Buul-Offers, and
E J Roza-de Jongh, and
M Feijlbrief, and
J Branger, and
E van Rongen
November 1992,
BioEssays : news and reviews in molecular, cellular and developmental biology,
A W van der Kamp, and
S C van Buul-Offers, and
E J Roza-de Jongh, and
M Feijlbrief, and
J Branger, and
E van Rongen
October 1983,
British journal of experimental pathology,
A W van der Kamp, and
S C van Buul-Offers, and
E J Roza-de Jongh, and
M Feijlbrief, and
J Branger, and
E van Rongen
January 1984,
Neurochemical pathology,
A W van der Kamp, and
S C van Buul-Offers, and
E J Roza-de Jongh, and
M Feijlbrief, and
J Branger, and
E van Rongen
January 2005,
Physiological research,
A W van der Kamp, and
S C van Buul-Offers, and
E J Roza-de Jongh, and
M Feijlbrief, and
J Branger, and
E van Rongen
April 1994,
European journal of orthodontics,
A W van der Kamp, and
S C van Buul-Offers, and
E J Roza-de Jongh, and
M Feijlbrief, and
J Branger, and
E van Rongen
March 1954,
Bollettino della Societa italiana di biologia sperimentale,
A W van der Kamp, and
S C van Buul-Offers, and
E J Roza-de Jongh, and
M Feijlbrief, and
J Branger, and
E van Rongen
August 1985,
Developmental biology,
A W van der Kamp, and
S C van Buul-Offers, and
E J Roza-de Jongh, and
M Feijlbrief, and
J Branger, and
E van Rongen
January 1989,
Biochemical Society symposium,
