The prognosis and development of pulmonary hypertension in idiopathic diffuse interstitial lung fibrosis. 1984

V Jezek

The prognosis of patients with idiopathic diffuse interstitial lung fibrosis is extremely variable and depends mainly on the presence and degree of pulmonary arterial hypertension. The incidence of pulmonary arterial hypertension in idiopathic diffuse interstitial lung fibrosis is not exactly known. We concluded from our study that in nonselected symptomatic patients about 50% have normal pulmonary arterial pressure and that advanced pulmonary arterial hypertension (over 30 mmHg) is present in about 10% of cases. The development of pulmonary arterial hypertension in idiopathic diffuse interstitial lung fibrosis, though generally slow, is very different in individual cases. We noted fast development of advanced pulmonary arterial hypertension within 2-3 years as well as stabilized normal pressure for 20 years or more. Further behaviour of pulmonary arterial pressure may not be safely predicted from any value in a first functional examination except in patients with initial advanced pulmonary arterial hypertension; they all either maintain or even increase their pulmonary arterial pressure and their 3-year mortality is over 50%. It is concluded that the knowledge of haemodynamic data not only improves our understanding of idiopathic diffuse interstitial lung fibrosis, but also enables us to determine the prognosis with a fair amount of accuracy.

UI MeSH Term Description Entries
D006976 Hypertension, Pulmonary Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES. Pulmonary Hypertension
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011379 Prognosis A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations. Prognostic Factor,Prognostic Factors,Factor, Prognostic,Factors, Prognostic,Prognoses
D011651 Pulmonary Artery The short wide vessel arising from the conus arteriosus of the right ventricle and conveying unaerated blood to the lungs. Arteries, Pulmonary,Artery, Pulmonary,Pulmonary Arteries
D011658 Pulmonary Fibrosis A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death. Alveolitis, Fibrosing,Idiopathic Diffuse Interstitial Pulmonary Fibrosis,Fibroses, Pulmonary,Fibrosis, Pulmonary,Pulmonary Fibroses,Alveolitides, Fibrosing,Fibrosing Alveolitides,Fibrosing Alveolitis
D001794 Blood Pressure PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS. Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults

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