-transparent.png){kind=logo}
The present study assessed the effects of ethanol and naloxone on the extinction of a jump-up avoidance response in Sprague-Dawley rats. Rats were first trained to jump onto a shelf to escape or avoid shock (0.5 mA). Upon reaching an acquisition criterion of 8 consecutive avoidance trials, animals were removed from the apparatus and exposed to 1 of 4 doses of ethanol (0, 1.0, 2.0, or 2.5 g/kg), and either naloxone (3 mg/kg) or saline. Rats were then returned to the conditioning apparatus with the shock turned off, and resistance to extinction was assessed. Ethanol had biphasic effects with low doses (1 g/kg) facilitating, and higher doses (2 and 2.5 g/kg) suppressing number of extinction responses by comparison to controls. Naloxone did not influence the course of extinction, and did not reverse any of the effects of ethanol. These results did not support the hypothesis that the effects of ethanol on aversively-motivated behavior are opioid-mediated.
M Galizio, and
B A Spencer, and
S C Smaltz, and
Y Sayed
November 1989,
Pharmacology, biochemistry, and behavior,
M Galizio, and
B A Spencer, and
S C Smaltz, and
Y Sayed
May 1984,
Drug and alcohol dependence,
M Galizio, and
B A Spencer, and
S C Smaltz, and
Y Sayed
September 2017,
Psychopharmacology,
M Galizio, and
B A Spencer, and
S C Smaltz, and
Y Sayed
June 1996,
Alcoholism, clinical and experimental research,
M Galizio, and
B A Spencer, and
S C Smaltz, and
Y Sayed
December 2020,
Journal of sports science & medicine,
M Galizio, and
B A Spencer, and
S C Smaltz, and
Y Sayed
January 1985,
Physiology & behavior,
M Galizio, and
B A Spencer, and
S C Smaltz, and
Y Sayed
October 1966,
Animal behaviour,
M Galizio, and
B A Spencer, and
S C Smaltz, and
Y Sayed
February 1974,
Behaviour research and therapy,
M Galizio, and
B A Spencer, and
S C Smaltz, and
Y Sayed
December 1997,
Pharmacology, biochemistry, and behavior,
M Galizio, and
B A Spencer, and
S C Smaltz, and
Y Sayed
August 1975,
Behavioral biology,
