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Eight patients with Functional Class III, seropositive, erosive rheumatoid arthritis unresponsive to remittive drugs each underwent nine aphereses over 3 weeks. Four had a 40-ml/kg plasma exchange and four others had a 40-ml/kg plasma exchange plus a mean 5.67 X 10(9) lymphocyte depletion. Both groups appeared to improve clinically. T and B cell counts and OK T4 and OK T8 ratios decreased in the lymphoplasmapheresis group. Phytohemagglutinin stimulation decreased in lymphoplasmapheresis and increased in plasmapheresis patients with significant comparisons (p = 0.02). These findings confirm and extend previous work. Plasmapheresis and lymphoplasmapheresis appear to have fundamentally different actions on lymphocyte function.
D J Wallace, and
M A Medici, and
S Nichols, and
J R Klinenberg, and
M Bick, and
R Gatti, and
D Goldfinger
July 1979,
Arthritis and rheumatism,
D J Wallace, and
M A Medici, and
S Nichols, and
J R Klinenberg, and
M Bick, and
R Gatti, and
D Goldfinger
November 1982,
The New England journal of medicine,
D J Wallace, and
M A Medici, and
S Nichols, and
J R Klinenberg, and
M Bick, and
R Gatti, and
D Goldfinger
June 1985,
Bollettino della Societa italiana di biologia sperimentale,
D J Wallace, and
M A Medici, and
S Nichols, and
J R Klinenberg, and
M Bick, and
R Gatti, and
D Goldfinger
January 1987,
La Pediatria medica e chirurgica : Medical and surgical pediatrics,
D J Wallace, and
M A Medici, and
S Nichols, and
J R Klinenberg, and
M Bick, and
R Gatti, and
D Goldfinger
February 1985,
Minerva pediatrica,
D J Wallace, and
M A Medici, and
S Nichols, and
J R Klinenberg, and
M Bick, and
R Gatti, and
D Goldfinger
June 1982,
The New England journal of medicine,
D J Wallace, and
M A Medici, and
S Nichols, and
J R Klinenberg, and
M Bick, and
R Gatti, and
D Goldfinger
January 1982,
Revista paulista de medicina,
D J Wallace, and
M A Medici, and
S Nichols, and
J R Klinenberg, and
M Bick, and
R Gatti, and
D Goldfinger
October 1983,
The New England journal of medicine,
D J Wallace, and
M A Medici, and
S Nichols, and
J R Klinenberg, and
M Bick, and
R Gatti, and
D Goldfinger
January 1984,
Revmatologiia (Moscow, Russia),
D J Wallace, and
M A Medici, and
S Nichols, and
J R Klinenberg, and
M Bick, and
R Gatti, and
D Goldfinger
January 1967,
Reumatologia,
