Biomaterial Database

Anterior third ventricle (A3V) lesions and homeostasis regulation. 1984

E Chiaraviglio, and M F Pérez Guaita

Small electrolytic lesions of A3V including the organum vasculosum lamina terminalis (OVLT) made in adult male rats resulted in 50% inhibition of 1.8% NaCl solution intake induced by peritoneal dialysis and significant enhancement of water-deprivation induced thirst. However water intake induced by hypertonic saline was unchanged. Daily water intake fell in the first post-lesion day, increasing thereafter; marked hyperdipsia was seen in some animals. Daily urinary output exceeded water intake. Further, these animals became hypernatremic. Following 24 h water deprivation, urinary excretion of a gastric water load was 18% greater in lesioned than in control animals. These results suggest that A3V lesioned animals fall to regulate fluids and electrolyte homeostasis, perhaps by disruption of an inhibitory feed back loop between the OVLT and other circumventricular structures.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D009318	Natriuresis	Sodium excretion by URINATION.	Natriureses
D011188	Potassium	An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE.
D001826	Body Fluids	Liquid components of living organisms.	Body Fluid,Fluid, Body,Fluids, Body
D002940	Circadian Rhythm	The regular recurrence, in cycles of about 24 hours, of biological processes or activities, such as sensitivity to drugs or environmental and physiological stimuli.	Diurnal Rhythm,Nyctohemeral Rhythm,Twenty-Four Hour Rhythm,Nycthemeral Rhythm,Circadian Rhythms,Diurnal Rhythms,Nycthemeral Rhythms,Nyctohemeral Rhythms,Rhythm, Circadian,Rhythm, Diurnal,Rhythm, Nycthemeral,Rhythm, Nyctohemeral,Rhythm, Twenty-Four Hour,Rhythms, Circadian,Rhythms, Diurnal,Rhythms, Nycthemeral,Rhythms, Nyctohemeral,Rhythms, Twenty-Four Hour,Twenty Four Hour Rhythm,Twenty-Four Hour Rhythms
D004027	Diencephalon	The paired caudal parts of the PROSENCEPHALON from which the THALAMUS; HYPOTHALAMUS; EPITHALAMUS; and SUBTHALAMUS are derived.	Interbrain,Interbrains
D004231	Diuresis	An increase in the excretion of URINE. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)	Diureses
D004326	Drinking	The consumption of liquids.	Water Consumption,Water Intake,Drinkings
D006706	Homeostasis	The processes whereby the internal environment of an organism tends to remain balanced and stable.	Autoregulation
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia