Biomaterial Database

Excretion of penicillins in bovine milk following intramuscular administration. 1984

J P Moretain, and J Boisseau

The kinetics of elimination into milk of sodium penicillin G, procaine penicillin G, benzathine penicillin G, ampicillin and amoxycillin residues have been determined after intramuscular administration of eleven drugs chosen among those commercially available in France. These investigations will be used as a basis to estimate and harmonize the withdrawal times demanded for veterinary drugs. The quantitative analysis of residues was carried out by a cylinder plate microbiological method with Bacillus stearothermophilus as test organism. The threshold of detection is 0.001 unit (or micrograms)/ml of milk. The mean durations of elimination are four milkings for the association sodium penicillin G and procaine penicillin G, from seven to eight milkings for procaine penicillin G alone, from 19 to 33 milkings for benzathine penicillin G, and from three to five milkings for ampicillin and amoxycillin.

UI	MeSH Term	Description	Entries
D007273	Injections, Intramuscular	Forceful administration into a muscle of liquid medication, nutrient, or other fluid through a hollow needle piercing the muscle and any tissue covering it.	Intramuscular Injections,Injection, Intramuscular,Intramuscular Injection
D007700	Kinetics	The rate dynamics in chemical or physical systems.
D008892	Milk	The off-white liquid secreted by the mammary glands of humans and other mammals. It contains proteins, sugar, lipids, vitamins, and minerals.	Cow Milk,Cow's Milk,Milk, Cow,Milk, Cow's
D010406	Penicillins	A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nucleus is the chief structural requirement for biological activity. The side-chain structure determines many of the antibacterial and pharmacological characteristics. (Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1065)	Antibiotics, Penicillin,Penicillin,Penicillin Antibiotics
D002417	Cattle	Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.	Beef Cow,Bos grunniens,Bos indicus,Bos indicus Cattle,Bos taurus,Cow,Cow, Domestic,Dairy Cow,Holstein Cow,Indicine Cattle,Taurine Cattle,Taurus Cattle,Yak,Zebu,Beef Cows,Bos indicus Cattles,Cattle, Bos indicus,Cattle, Indicine,Cattle, Taurine,Cattle, Taurus,Cattles, Bos indicus,Cattles, Indicine,Cattles, Taurine,Cattles, Taurus,Cow, Beef,Cow, Dairy,Cow, Holstein,Cows,Dairy Cows,Domestic Cow,Domestic Cows,Indicine Cattles,Taurine Cattles,Taurus Cattles,Yaks,Zebus
D005260	Female		Females
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia