Biomaterial Database

Critical tests of morantel-trichlorfon paste formulation against internal parasites of the horse. 1984

J H Drudge, and E T Lyons, and S C Tolliver

Critical tests were completed on six horses to evaluate the antiparasitic activity of a paste formulation mixture of morantel citrate and trichlorfon, administered intraorally at the dose rate of 6 mg morantel base kg-1 and trichlorfon at 30 mg kg-1. Aggregate average removals were: 78% for two horses infected with 2nd instar Gasterophilus intestinalis; 100% for one infected with 2nd instar G. nasalis; 96% for six infected with 3rd instar G. intestinalis; 100% for four infected with 3rd instar G. nasalis; 100% for five infected with Parascaris equorum; 100% for one infected with mature Oxyuris equi; 100% for five infected with Strongylus vulgaris; 72% for five infected with S. edentatus; and partial removal (25%) of Anoplocephala perfoliata infection from one infected animal. Pre- and post-treatment EPG and LPG data indicated a reduction of 97% of the mature small strongyle infections. Evidence of toxicosis was not observed in any of the horses.

UI	MeSH Term	Description	Entries
D009015	Morantel	Antinematodal agent used mainly for livestock.	Morantel Tartrate,Paratect,Tartrate, Morantel
D009198	Myiasis	The invasion of living tissues of man and other mammals by dipterous larvae.	Fly Strike,Maggot Infestations,Fly Strikes,Infestation, Maggot,Infestations, Maggot,Maggot Infestation,Myiases
D009349	Nematode Infections	Infections by nematodes, general or unspecified.	Infections, Nematode,Infection, Nematode,Nematode Infection
D009824	Ointments	Semisolid preparations used topically for protective emollient effects or as a vehicle for local administration of medications. Ointment bases are various mixtures of fats, waxes, animal and plant oils and solid and liquid hydrocarbons.	Ointment,Paste,Pastes,Salve,Unguent,Salves,Skin Ointment,Unguents,Ointment, Skin
D010123	Oxyuriasis	Infection with nematodes of the superfamily OXYUROIDEA.	Aspiculariasis,Aspiculariases,Oxyuriases
D011743	Pyrimidines	A family of 6-membered heterocyclic compounds occurring in nature in a wide variety of forms. They include several nucleic acid constituents (CYTOSINE; THYMINE; and URACIL) and form the basic structure of the barbiturates.
D002590	Cestode Infections	Infections with true tapeworms of the helminth subclass CESTODA.	Bertielliasis,Cenuriasis,Coenuriasis,Dipylidiasis,Raillietiniasis,Tapeworm Infection,Bertielliases,Cenuriases,Cestode Infection,Coenuriases,Dipylidiases,Infection, Cestode,Infection, Tapeworm,Infections, Cestode,Infections, Tapeworm,Raillietiniases,Tapeworm Infections
D004341	Drug Evaluation	Any process by which toxicity, metabolism, absorption, elimination, preferred route of administration, safe dosage range, etc., for a drug or group of drugs is determined through clinical assessment in humans or veterinary animals.	Evaluation Studies, Drug,Drug Evaluation Studies,Drug Evaluation Study,Drug Evaluations,Evaluation Study, Drug,Evaluation, Drug,Evaluations, Drug,Studies, Drug Evaluation,Study, Drug Evaluation
D004359	Drug Therapy, Combination	Therapy with two or more separate preparations given for a combined effect.	Combination Chemotherapy,Polychemotherapy,Chemotherapy, Combination,Combination Drug Therapy,Drug Polytherapy,Therapy, Combination Drug,Chemotherapies, Combination,Combination Chemotherapies,Combination Drug Therapies,Drug Polytherapies,Drug Therapies, Combination,Polychemotherapies,Polytherapies, Drug,Polytherapy, Drug,Therapies, Combination Drug
D006734	Horse Diseases	Diseases of domestic and wild horses of the species Equus caballus.	Equine Diseases,Disease, Equine,Disease, Horse,Diseases, Equine,Diseases, Horse,Equine Disease,Horse Disease