Biomaterial Database

[Effect of valeprotriate on spontaneous motor activity in mice]. 1984

J Hölzl, and C Fink

The purpose of the present investigation was to study effects of valtrate and acetoxyvaltrate hydrine on locomotor activity of mice. The method is characterized by the control of single animals over two total periods of activity. A differentiated effect curve caused by the substances during 24 h was maintained and an effect by doses used in therapy became evident. Locomotor activity was significantly inhibited by valtrate in a concentration of 0.1 mg/kg injected i.v. and 0.5 mg/kg if applied p.o. Higher concentrations did not result in an elongated effect. Acetoxyvaltrate hydrine, which is characterized by missing epoxide structure, caused reduced locomotor activity in a concentration of 4 mg/kg.

UI	MeSH Term	Description	Entries
D009043	Motor Activity	Body movements of a human or an animal as a behavioral phenomenon.	Activities, Motor,Activity, Motor,Motor Activities
D011714	Pyrans		Pyran
D004305	Dose-Response Relationship, Drug	The relationship between the dose of an administered drug and the response of the organism to the drug.	Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D005260	Female		Females
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013997	Time Factors	Elements of limited time intervals, contributing to particular results or situations.	Time Series,Factor, Time,Time Factor
D051379	Mice	The common name for the genus Mus.	Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus
D039823	Iridoids	A type of MONOTERPENES, derived from geraniol. They have the general form of cyclopentanopyran, but in some cases, one of the rings is broken as in the case of secoiridoid. They are different from the similarly named iridals (TRITERPENES).	Iridoid,Iridoid Derivatives,Secoiridoids,Iridoid Aglycones,Aglycones, Iridoid,Derivatives, Iridoid