-transparent.png){kind=logo}
Serial saliva cortisol measurements were used to assess pituitary-adrenal function in a group of asthmatic children treated with beclomethasone dipropionate (400 micrograms daily). Asthmatic children who were not being treated with steroids and normal children were also studied for comparison. A diurnal cortisol rhythm was observed in all three groups. Early morning cortisol concentrations were significantly higher in the group treated with beclomethasone dipropionate than in the normal children; this may indicate a stress induced response to decreased morning peak expiratory flow. In both groups, plasma and salivary cortisol responses after adrenocorticotrophic hormone stimulation test were normal but peak cortisol concentrations showed a 7 fold increase over basal values in saliva compared with a three fold increase in plasma. Beclomethasone dipropionate does not suppress pituitary-adrenal function in children when used in recommended doses. Serial measurement of the salivary cortisol concentration is a simple, safe, and sensitive method for the routine monitoring of adrenal function in children treated with this steroid. Monitoring may be supplemented with an assessment of the adrenal response to adrenocorticotrophic hormone stimulation, if necessary.
H Williams, and
G F Read, and
E R Verrier-Jones, and
I A Hughes
May 1999,
Equine veterinary journal,
H Williams, and
G F Read, and
E R Verrier-Jones, and
I A Hughes
May 1999,
Respiratory medicine,
H Williams, and
G F Read, and
E R Verrier-Jones, and
I A Hughes
October 1990,
Thorax,
H Williams, and
G F Read, and
E R Verrier-Jones, and
I A Hughes
September 1973,
Clinical allergy,
H Williams, and
G F Read, and
E R Verrier-Jones, and
I A Hughes
June 1986,
Lancet (London, England),
H Williams, and
G F Read, and
E R Verrier-Jones, and
I A Hughes
February 1991,
The Journal of pediatrics,
H Williams, and
G F Read, and
E R Verrier-Jones, and
I A Hughes
February 1993,
Annals of allergy,
H Williams, and
G F Read, and
E R Verrier-Jones, and
I A Hughes
July 1973,
Acta allergologica,
H Williams, and
G F Read, and
E R Verrier-Jones, and
I A Hughes
October 2007,
The Journal of asthma : official journal of the Association for the Care of Asthma,
H Williams, and
G F Read, and
E R Verrier-Jones, and
I A Hughes
July 1998,
Respiratory medicine,
