A field trial of 1alpha-hydroxycholecalciferol (1alpha-OH D3) in the prevention of milk fever. 1978

D C Davies, and W M Allen, and M N Hoare, and J M Pott, and C J Riley, and B F Sansom, and J R Stenton, and M J Vagg

The efficacy of 1alpha-OH cholecalciferol for the prevention of milk fever has been tested in a controlled field trial using 597 cows on 19 farms all of which had previously had a high incidence of milk fever. Of 293 cows receiving 1alpha-OH cholecalciferol 34 had milk fever and of 304 control cows 51 had milk fever. Although there was an apparent efficacy of 31 per cent the difference in incidence was not statistically significant. There was no effect if 1alpha-OH cholecalciferol was administered less than 24 hours before the cows succumbed to milk fever. However, if 1alpha-OH cholecalciferol was administered more than 24 hours and less than one week before the occurrence of milk fever the efficacy increased to 61 per cent and the effect was highly significant.

UI MeSH Term Description Entries
D008274 Magnesium A metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION.
D010319 Parturient Paresis A disease of pregnant and lactating cows and ewes leading to generalized paresis and death. The disease, which is characterized by hypocalcemia, occurs at or shortly after parturition in cows and within weeks before or after parturition in ewes. Milk Fever, Animal,Animal Milk Fever,Fever, Animal Milk,Pareses, Parturient,Paresis, Parturient,Parturient Pareses
D010758 Phosphorus A non-metal element that has the atomic symbol P, atomic number 15, and atomic weight 31. It is an essential element that takes part in a broad variety of biochemical reactions. Black Phosphorus,Phosphorus-31,Red Phosphorus,White Phosphorus,Yellow Phosphorus,Phosphorus 31,Phosphorus, Black,Phosphorus, Red,Phosphorus, White,Phosphorus, Yellow
D010919 Placebos Any dummy medication or treatment. Although placebos originally were medicinal preparations having no specific pharmacological activity against a targeted condition, the concept has been extended to include treatments or procedures, especially those administered to control groups in clinical trials in order to provide baseline measurements for the experimental protocol. Sham Treatment
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D002118 Calcium A basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes. Coagulation Factor IV,Factor IV,Blood Coagulation Factor IV,Calcium-40,Calcium 40,Factor IV, Coagulation
D002417 Cattle Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor. Beef Cow,Bos grunniens,Bos indicus,Bos indicus Cattle,Bos taurus,Cow,Cow, Domestic,Dairy Cow,Holstein Cow,Indicine Cattle,Taurine Cattle,Taurus Cattle,Yak,Zebu,Beef Cows,Bos indicus Cattles,Cattle, Bos indicus,Cattle, Indicine,Cattle, Taurine,Cattle, Taurus,Cattles, Bos indicus,Cattles, Indicine,Cattles, Taurine,Cattles, Taurus,Cow, Beef,Cow, Dairy,Cow, Holstein,Cows,Dairy Cows,Domestic Cow,Domestic Cows,Indicine Cattles,Taurine Cattles,Taurus Cattles,Yaks,Zebus
D002418 Cattle Diseases Diseases of domestic cattle of the genus Bos. It includes diseases of cows, yaks, and zebus. Bovine Diseases,Bovine Disease,Cattle Disease,Disease, Bovine,Disease, Cattle,Diseases, Bovine,Diseases, Cattle
D005260 Female Females
D006887 Hydroxycholecalciferols Hydroxy analogs of vitamin D 3; (CHOLECALCIFEROL); including CALCIFEDIOL; CALCITRIOL; and 24,25-DIHYDROXYVITAMIN D 3. Hydroxyvitamins D,Hydroxycholecalciferol

Related Publications

D C Davies, and W M Allen, and M N Hoare, and J M Pott, and C J Riley, and B F Sansom, and J R Stenton, and M J Vagg
May 1978, The Veterinary record,
D C Davies, and W M Allen, and M N Hoare, and J M Pott, and C J Riley, and B F Sansom, and J R Stenton, and M J Vagg
September 1981, Clinical nephrology,
D C Davies, and W M Allen, and M N Hoare, and J M Pott, and C J Riley, and B F Sansom, and J R Stenton, and M J Vagg
May 1977, Calcified tissue research,
D C Davies, and W M Allen, and M N Hoare, and J M Pott, and C J Riley, and B F Sansom, and J R Stenton, and M J Vagg
July 1975, Chemical & pharmaceutical bulletin,
D C Davies, and W M Allen, and M N Hoare, and J M Pott, and C J Riley, and B F Sansom, and J R Stenton, and M J Vagg
August 1978, The Veterinary record,
D C Davies, and W M Allen, and M N Hoare, and J M Pott, and C J Riley, and B F Sansom, and J R Stenton, and M J Vagg
January 1984, Acta veterinaria Scandinavica,
D C Davies, and W M Allen, and M N Hoare, and J M Pott, and C J Riley, and B F Sansom, and J R Stenton, and M J Vagg
August 1967, The Veterinary record,
D C Davies, and W M Allen, and M N Hoare, and J M Pott, and C J Riley, and B F Sansom, and J R Stenton, and M J Vagg
January 1978, The American journal of medicine,
D C Davies, and W M Allen, and M N Hoare, and J M Pott, and C J Riley, and B F Sansom, and J R Stenton, and M J Vagg
December 1977, American journal of veterinary research,
D C Davies, and W M Allen, and M N Hoare, and J M Pott, and C J Riley, and B F Sansom, and J R Stenton, and M J Vagg
August 1973, Proceedings of the National Academy of Sciences of the United States of America,
Copied contents to your clipboard!