Biomaterial Database

[Treatment of diabetic cystoid macular edema by argon laser photocoagulation]. 1984

A Gaudric, and E Ramioul, and G Chaine, and G Coscas

Diabetic maculopathy remains the main cause of poor visual acuity in diabetic retinopathy either proliferative or non proliferative. Although photocoagulation in the macular area is known to be effective in treatment of exudates, results in treatment of cystoid macular edema (CME) are still questionable. 36 eyes with diabetic CME and non ischaemic capillary bed were treated with argon laser photocoagulation in the macular area. Two groups of patients were studied. Group I consisted of 16 eyes with CME and with circinate exudates in the paramacular area. Mild argon burns (50-200) were applied on the microvascular abnormalities and on the pigment epithelium in the center of the circinate exudates. The macula (1500 of diameter) was not treated in this group. As expected, results on the exudates rings were good. CME disappeared in 43% of the cases, and regressed in 23% of the cases. Nevertheless 3 years after treatment the mean visual acuity was found to be slightly worse than before the treatment. Group II consisted of 20 eyes with CME, exudates were absent or scattered. Mild argon burns were applied on the area of macular cysts avoiding only the foveal avascular zone (500 of diameter). Exudates when present disappeared in all cases. CME disappeared in 80% of the cases and regressed in 15% of the cases. Three years after treatment mean visual acuity remained identical. Extensive review of the literature concerning the treatment of diabetic maculopathy shows a wide range of techniques and evaluation procedures. We propose the following method of treatment: when exudate rings are present with CME, treatment should be aimed first towards focal microvascular abnormalities avoiding the macular area. When exudates are absent or in cases of unchanged CME after extramacular photocoagulation, treatment should be aimed towards the microcystic area avoiding the foveal avascular zone, if visual acuity is less than 0,5.

UI	MeSH Term	Description	Entries
D007834	Lasers	An optical source that emits photons in a coherent beam. Light Amplification by Stimulated Emission of Radiation (LASER) is brought about using devices that transform light of varying frequencies into a single intense, nearly nondivergent beam of monochromatic radiation. Lasers operate in the infrared, visible, ultraviolet, or X-ray regions of the spectrum.	Masers,Continuous Wave Lasers,Pulsed Lasers,Q-Switched Lasers,Continuous Wave Laser,Laser,Laser, Continuous Wave,Laser, Pulsed,Laser, Q-Switched,Lasers, Continuous Wave,Lasers, Pulsed,Lasers, Q-Switched,Maser,Pulsed Laser,Q Switched Lasers,Q-Switched Laser
D008266	Macula Lutea	An oval area in the retina, 3 to 5 mm in diameter, usually located temporal to the posterior pole of the eye and slightly below the level of the optic disk. It is characterized by the presence of a yellow pigment diffusely permeating the inner layers, contains the fovea centralis in its center, and provides the best phototropic visual acuity. It is devoid of retinal blood vessels, except in its periphery, and receives nourishment from the choriocapillaris of the choroid. (From Cline et al., Dictionary of Visual Science, 4th ed)	Lutea, Macula,Luteas, Macula,Macula Luteas
D008269	Macular Edema	Fluid accumulation in the outer layer of the MACULA LUTEA that results from intraocular or systemic insults. It may develop in a diffuse pattern where the macula appears thickened or it may acquire the characteristic petaloid appearance referred to as cystoid macular edema. Although macular edema may be associated with various underlying conditions, it is most commonly seen following intraocular surgery, venous occlusive disease, DIABETIC RETINOPATHY, and posterior segment inflammatory disease. (From Survey of Ophthalmology 2004; 49(5) 470-90)	Central Retinal Edema, Cystoid,Cystoid Macular Edema,Macular Edema, Cystoid,Cystoid Macular Dystrophy,Cystoid Macular Edema, Postoperative,Irvine-Gass Syndrome,Macular Dystrophy, Dominant Cystoid,Edema, Cystoid Macular,Edema, Macular,Irvine Gass Syndrome,Syndrome, Irvine-Gass
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D011446	Prospective Studies	Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.	Prospective Study,Studies, Prospective,Study, Prospective
D003930	Diabetic Retinopathy	Disease of the RETINA as a complication of DIABETES MELLITUS. It is characterized by the progressive microvascular complications, such as ANEURYSM, interretinal EDEMA, and intraocular PATHOLOGIC NEOVASCULARIZATION.	Diabetic Retinopathies,Retinopathies, Diabetic,Retinopathy, Diabetic
D005260	Female		Females
D005451	Fluorescein Angiography	Visualization of a vascular system after intravenous injection of a fluorescein solution. The images may be photographed or televised. It is used especially in studying the retinal and uveal vasculature.	Fluorescence Angiography,Fundus Fluorescence Photography,Angiography, Fluorescein,Angiography, Fluorescence,Fluorescence Photography, Fundus,Photography, Fundus Fluorescence
D005584	Fovea Centralis	An area approximately 1.5 millimeters in diameter within the macula lutea where the retina thins out greatly because of the oblique shifting of all layers except the pigment epithelium layer. It includes the sloping walls of the fovea (clivus) and contains a few rods in its periphery. In its center (foveola) are the cones most adapted to yield high visual acuity, each cone being connected to only one ganglion cell. (Cline et al., Dictionary of Visual Science, 4th ed)