The relationship between blood alcohol levels and aggression in mice. 1984

D Benton, and R Smoothy

Previous reports of the impact of ethanol on murine aggression have produced inconsistent findings; some workers have found that low doses of ethanol increase aggression whereas others have reported either no effect or a suppression. The present study examined one variable that may help to account for these inconsistencies, namely the level of blood alcohol at various times after administration. Acute doses of 0.5, 1, 2 g/kg ethanol all potently suppressed fighting in mice. However, there was no simple relationship between blood alcohol levels and fighting. It appeared that the level of blood alcohol, whether these levels were falling and the time since alcohol was cleared from the blood were all factors that influenced the drugs anti-aggressive influence.

UI MeSH Term Description Entries
D008297 Male Males
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000374 Aggression Behavior which may be manifested by destructive and attacking action which is verbal or physical, by covert attitudes of hostility or by obstructionism. Aggressions
D000431 Ethanol A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES. Alcohol, Ethyl,Absolute Alcohol,Grain Alcohol,Alcohol, Absolute,Alcohol, Grain,Ethyl Alcohol
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D051379 Mice The common name for the genus Mus. Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus

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