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The level of fructose 2,6-bisphosphate is markedly decreased in the rat V.renal gland in diabetes, falling to 23% of the control value. There is parallel decrease in the flux of 14C-labelled glucose through the glycolytic route and tricarboxylic acid cycle. Only minimal changes in hexokinase (EC 2.7.1.1.), a 22% decrease in Type I hexokinase of the soluble fraction, were observed, highlighting the probable significant involvement of fructose 2,6-bisphosphate in the regulation of glycolysis in the adrenal. In contrast, there was evidence for a marked rise in the flux of glucose through the pentose phosphate pathway, which may be linked to enhanced corticoid synthesis in the diabetic state.
M Sochor, and
A M Gonzalez, and
P McLean
January 1988,
The International journal of biochemistry,
M Sochor, and
A M Gonzalez, and
P McLean
April 1984,
FEBS letters,
M Sochor, and
A M Gonzalez, and
P McLean
December 1993,
Biochemical medicine and metabolic biology,
M Sochor, and
A M Gonzalez, and
P McLean
January 1984,
Current topics in cellular regulation,
M Sochor, and
A M Gonzalez, and
P McLean
June 1986,
Biochimica et biophysica acta,
M Sochor, and
A M Gonzalez, and
P McLean
January 1990,
The International journal of biochemistry,
M Sochor, and
A M Gonzalez, and
P McLean
October 1985,
Diabetes,
M Sochor, and
A M Gonzalez, and
P McLean
November 1981,
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M Sochor, and
A M Gonzalez, and
P McLean
June 1983,
Biochemical Society transactions,
M Sochor, and
A M Gonzalez, and
P McLean
December 1985,
Archivos de biologia y medicina experimentales,
