-transparent.png){kind=logo}
Fifty-four patients with advanced ovarian cancer have been treated with combination chemotherapy using cyclophosphamide, adriamycin and cis-platinum. The toxicity of the regimen was manageable but few patients were prepared to tolerate more than 6 months of treatment. Those in complete clinical remission at that time were offered second-look laparotomy and if apparently free of disease, therapy was discontinued. Forty-seven patients could be assessed of whom 33 had had no previous therapy. Twenty-two of these were clinically free of disease after completion of chemotherapy of whom 12 had no detectable disease at second-look laparotomy. Of 14 patients who had failed previous therapy only one remains clinically free of disease. The results in the untreated patients demonstrate the primary importance of bulk reduction at initial laparotomy. The use of the regimen in patients who have failed on previous treatment or in patients with bulk disease seems to be palliative and the toxicity should be assessed in this context.
R Milsted, and
G Sangster, and
S Kaye, and
K Calman, and
J Cordiner, and
W Soutter, and
W Barr, and
D Cunningham, and
M Soukop, and
J Kennedy
January 1982,
Oncology,
R Milsted, and
G Sangster, and
S Kaye, and
K Calman, and
J Cordiner, and
W Soutter, and
W Barr, and
D Cunningham, and
M Soukop, and
J Kennedy
October 1981,
Gynecologic oncology,
R Milsted, and
G Sangster, and
S Kaye, and
K Calman, and
J Cordiner, and
W Soutter, and
W Barr, and
D Cunningham, and
M Soukop, and
J Kennedy
June 1985,
Gynecologic oncology,
R Milsted, and
G Sangster, and
S Kaye, and
K Calman, and
J Cordiner, and
W Soutter, and
W Barr, and
D Cunningham, and
M Soukop, and
J Kennedy
February 1981,
Cancer,
R Milsted, and
G Sangster, and
S Kaye, and
K Calman, and
J Cordiner, and
W Soutter, and
W Barr, and
D Cunningham, and
M Soukop, and
J Kennedy
January 1986,
Oncology,
R Milsted, and
G Sangster, and
S Kaye, and
K Calman, and
J Cordiner, and
W Soutter, and
W Barr, and
D Cunningham, and
M Soukop, and
J Kennedy
August 1977,
Cancer treatment reports,
R Milsted, and
G Sangster, and
S Kaye, and
K Calman, and
J Cordiner, and
W Soutter, and
W Barr, and
D Cunningham, and
M Soukop, and
J Kennedy
August 1984,
Gan to kagaku ryoho. Cancer & chemotherapy,
R Milsted, and
G Sangster, and
S Kaye, and
K Calman, and
J Cordiner, and
W Soutter, and
W Barr, and
D Cunningham, and
M Soukop, and
J Kennedy
August 1980,
Cancer,
R Milsted, and
G Sangster, and
S Kaye, and
K Calman, and
J Cordiner, and
W Soutter, and
W Barr, and
D Cunningham, and
M Soukop, and
J Kennedy
June 1985,
European journal of cancer & clinical oncology,
R Milsted, and
G Sangster, and
S Kaye, and
K Calman, and
J Cordiner, and
W Soutter, and
W Barr, and
D Cunningham, and
M Soukop, and
J Kennedy
January 1983,
Cancer chemotherapy and pharmacology,
